Technology Process of Cycloheptanone,
4-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-4-phenyl-
There total 7 articles about Cycloheptanone,
4-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]-4-phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 1.5h;
Molecular sieve;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Grubbs catalyst first generation / dichloromethane / 1 h / Reflux
2.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C
3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C
5.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
5.2: 0 - 20 °C
6.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve
With
Grubbs catalyst first generation; sodium tetrahydroborate; borane-THF; sodium hydride; diisobutylaluminium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
1.1: |Grubbs Olefin Metathesis;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C
2.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C
4.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
4.2: 0 - 20 °C
5.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve
With
sodium tetrahydroborate; borane-THF; sodium hydride; diisobutylaluminium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.bmc.2013.02.010
