Technology Process of 2(1H)-Azocinone,
6-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-6-phenyl-
There total 8 articles about 2(1H)-Azocinone,
6-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-6-phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide; trifluoroacetic acid;
In
water; benzene;
at 65 ℃;
for 1h;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
1.2: 2 h / 20 °C
2.1: Grubbs catalyst first generation / dichloromethane / 1 h / Reflux
3.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C
4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C
6.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
6.2: 0 - 20 °C
7.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve
8.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C
With
Grubbs catalyst first generation; sodium tetrahydroborate; sodium azide; borane-THF; sodium hydride; diisobutylaluminium hydride; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; benzene;
2.1: |Grubbs Olefin Metathesis / 8.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C
2.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
2.2: 0 - 20 °C
3.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve
4.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C
With
sodium azide; borane-THF; sodium hydride; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; benzene;
4.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010
