1-Pyrrolidinecarboxylic acid, 2-[[(4-chlorophenyl)methoxy]methyl]-4-[[(1,2-dihydro-1-oxo-5-isoquinolin yl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-, 1,1-dimethylethyl ester, (2S,4S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[(4-chlorophenyl)methoxy]methyl]-4-[[(1,2-dihydro-1-oxo-5-isoquinolin yl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-, 1,1-dimethylethyl ester, (2S,4S)-
CAS No.:874447-87-7
Molecular Formula:C32H44ClN3O7SSi
Molecular Weight:678.322
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[[(4-chlorophenyl)methoxy]methyl]-4-[[(1,2-dihydro-1-oxo-5-isoquinolin
yl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-, 1,1-dimethylethyl
ester, (2S,4S)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[[(4-chlorophenyl)methoxy]methyl]-4-[[(1,2-dihydro-1-oxo-5-isoquinolin yl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-, 1,1-dimethylethyl ester, (2S,4S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[(4-chlorophenyl)methoxy]methyl]-4-[[(1,2-dihydro-1-oxo-5-isoquinolin yl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-, 1,1-dimethylethyl ester, (2S,4S)-

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Purity/Quality:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[(4-chlorophenyl)methoxy]methyl]-4-[[(1,2-dihydro-1-oxo-5-isoquinolin yl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-, 1,1-dimethylethyl ester, (2S,4S)-

There total 11 articles about 1-Pyrrolidinecarboxylic acid, 2-[[(4-chlorophenyl)methoxy]methyl]-4-[[(1,2-dihydro-1-oxo-5-isoquinolin yl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-, 1,1-dimethylethyl ester, (2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 874447-86-6
(2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-chloroisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 874447-87-7
(2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-hydroxyisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran; at 80 ℃; for 2h;
DOI:10.1016/j.bmc.2005.09.055

Reference yield:

: 141519-77-9
1-chloroisoquinoline-5-sulphonyl chloride

: 874447-87-7
(2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-hydroxyisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / triethylamine; DMAP / CH₂Cl₂ / 72 h / 20 °C

2: 100 percent / NaH / tetrahydrofuran / 1.5 h / 0 °C

3: 63 percent / potassium trimethylsilanolate / tetrahydrofuran / 2 h / 80 °C

With dmap; potassium trimethylsilonate; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2005.09.055

Reference yield:

: (2S,4R)-2-hydroxymethyl-4-(tetrahydropyran-2-yl-oxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 874447-87-7
(2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-hydroxyisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 54 percent / KH / tetrahydrofuran / 48 h / 20 °C

2: 74 percent / PPTS / ethanol / 4 h / 55 °C

3: triethylamine / CH₂Cl₂ / 0 °C

4: sodium azide / dimethylformamide / 80 °C

5: 1.29 g / PPh₃ / tetrahydrofuran; H₂O / 18 h / 20 °C

6: 83 percent / triethylamine; DMAP / CH₂Cl₂ / 72 h / 20 °C

7: 100 percent / NaH / tetrahydrofuran / 1.5 h / 0 °C

8: 63 percent / potassium trimethylsilanolate / tetrahydrofuran / 2 h / 80 °C

With dmap; sodium azide; potassium trimethylsilonate; pyridinium p-toluenesulfonate; potassium hydride; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.09.055