1-Chloro-5-isoquinolinesulfonyl Chloride

Base Information

• Chemical Name: 1-Chloro-5-isoquinolinesulfonyl Chloride
• CAS No.: 141519-77-9
• Molecular Formula: C9H5 Cl2 N O2 S
• Molecular Weight: 262.11
• Hs Code.: 2933499090
• Mol file: 141519-77-9.mol

Synonyms:1-Chloroisoquinoline-5-sulfonylchloride

Chemical Property of 1-Chloro-5-isoquinolinesulfonyl Chloride

Chemical Property:

• PSA: 55.41000
• LogP: 3.89650
• Solubility.: Chloroform, Dichloromethane

Purity/Quality:

97% ^*data from raw suppliers

1-Chloro-5-isoquinolinesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Chloro-5-isoquinolinesulfonyl Chloride (cas# 141519-77-9) is a compound useful in organic synthesis.

Technology Process of 1-Chloro-5-isoquinolinesulfonyl Chloride

There total 3 articles about 1-Chloro-5-isoquinolinesulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chlorosulfonic acid (7790-94-5) + 1-chloroisoquinoline (19493-44-8) → 1-chloroisoquinoline-5-sulphonyl chloride (141519-77-9)

Guidance literature:

at 0 - 155 ℃; for 24h;

Reference yield: 80.0%

1-chloroisoquinoline (19493-44-8) → 1-chloroisoquinoline-5-sulphonyl chloride (141519-77-9)

Guidance literature:

With chlorosulfonic acid; at 125 ℃; for 72h;

DOI:10.1016/j.bmc.2005.09.055

Reference yield:

1-chloro-5-isoquinolinesulphonic acid (105627-80-3) → 1-chloroisoquinoline-5-sulphonyl chloride (141519-77-9)

Guidance literature:

In thionyl chloride; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1-chloroisoquinoline

chlorosulfonic acid

1-chloro-5-isoquinolinesulphonic acid

Downstream raw materials:

C₂₂H₂₀Cl₃N₃O₃S

1-chloro-isoquinoline-5-sulfonic acid (2-{[3-(2-benzyl-4-chloro-phenoxy)-propyl]-[bis-(4-methoxy-phenyl)-methyl]-amino}-ethyl)-amide

(2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-hydroxyisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4S)-2-(4-chlorobenzyloxymethyl)-4-[(1-chloroisoquinoline-5-sulfonyl)-(2-trimethylsilylethoxymethyl)amino]-pyrrolidine-1-carboxylic acid tert-butyl ester