2-Piperidinone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (5S,6S)-

Base Information

Chemical Name:2-Piperidinone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (5S,6S)-
CAS No.:874483-90-6
Molecular Formula:C26H47NO4Si2
Molecular Weight:493.834
Hs Code.:

2-Piperidinone,
5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsil
yl]oxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (5S,6S)-

Synonyms:

Suppliers and Price of 2-Piperidinone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (5S,6S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Piperidinone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (5S,6S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Piperidinone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (5S,6S)-

There total 3 articles about 2-Piperidinone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (5S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 874483-89-3
(5S,6S)-5-(tert-butyldimethylsilyloxy)-6-(hydroxymethyl)-1-(4-methoxybenzyl)piperidin-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 874483-90-6
(5S,6S)-5-(tert-butyldimethylsilyloxy)-6-[(tert-butyldimethylsilyloxy)methyl]-1-(4-methoxybenzyl)piperidin-2-one

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2005.09.112

Reference yield:

: 874483-86-0
6-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1-(4-methoxy-benzyl)-piperidin-2-one

: 874483-90-6
(5S,6S)-5-(tert-butyldimethylsilyloxy)-6-[(tert-butyldimethylsilyloxy)methyl]-1-(4-methoxybenzyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / Pd/C / ethanol / 8 h / 20 °C / 760 Torr

2: 57 percent / BF₃*OEt₂; Et₃SiH / CH₂Cl₂ / -78 - 20 °C

3: 92 percent / imidazole; DMAP / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; triethylsilane; dmap; boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.09.112

Reference yield:

: 874483-88-2
5-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-6-hydroxymethyl-1-(4-methoxy-benzyl)-piperidin-2-one

: 874483-90-6
(5S,6S)-5-(tert-butyldimethylsilyloxy)-6-[(tert-butyldimethylsilyloxy)methyl]-1-(4-methoxybenzyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / BF₃*OEt₂; Et₃SiH / CH₂Cl₂ / -78 - 20 °C

2: 92 percent / imidazole; DMAP / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; triethylsilane; dmap; boron trifluoride diethyl etherate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.09.112