2-(2-methoxy-ethoxy)-5-nitro-pyridine

Base Information

• Chemical Name: 2-(2-methoxy-ethoxy)-5-nitro-pyridine
• CAS No.: 874492-44-1
• Molecular Formula: C8H10N2O4
• Molecular Weight: 198.17600
• Mol file: 874492-44-1.mol

Synonyms:2-(2-methoxy-ethoxy)-5-nitro-pyridine;2-(2-Methoxy-aethoxy)-5-nitro-pyridin;Pyridine,2-(2-methoxyethoxy)-5-nitro;

Chemical Property of 2-(2-methoxy-ethoxy)-5-nitro-pyridine

Chemical Property:

• PSA: 77.17000
• LogP: 1.53820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-methoxy-ethoxy)-5-nitro-pyridine

There total 6 articles about 2-(2-methoxy-ethoxy)-5-nitro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-5-nitropyridine (4548-45-2) + 2-methoxy-ethanol (109-86-4,95507-80-5) → 2-(2-methoxyethoxy)-5-nitropyridine (874492-44-1)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

2-chloro-4-nitropyridine (23056-36-2) + 2-methoxy-ethanol (109-86-4,95507-80-5) → 2-(2-methoxyethoxy)-5-nitropyridine (874492-44-1)

Guidance literature:

With sodium hydride; at 20 ℃; for 0.833333h;

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) + sodium 2-methoxyethanolate (3139-99-9) → 2-(2-methoxyethoxy)-5-nitropyridine (874492-44-1)

Guidance literature:

With 2-methoxy-ethanol;

DOI:10.1021/ja01197a063

upstream raw materials:

2-chloro-5-nitropyridine

sodium 2-methoxyethanolate

2-methoxy-ethanol

2-chloro-4-nitropyridine

Downstream raw materials:

6-(2-methoxyethoxy)pyridin-3-ylamine

phenyl 6-(2-hydroxyethoxy)pyridin-3-ylcarbamate

phenyl 6-(2-methoxyethoxy)pyridin-3-ylcarbamate

1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-methoxyethoxy)pyridin-3-yl)urea