2-Chloro-4-nitropyridine

Base Information

Chemical Name:2-Chloro-4-nitropyridine
CAS No.:23056-36-2
Molecular Formula:C5H3ClN2O2
Molecular Weight:158.544
Hs Code.:29333990
European Community (EC) Number:627-980-8
DSSTox Substance ID:DTXSID50352743
Nikkaji Number:J1.710.515I
Wikidata:Q72456048
Mol file:23056-36-2.mol

Synonyms:2-chloro-4-nitropyridine

Suppliers and Price of 2-Chloro-4-nitropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-4-nitropyridine
10g
$ 525.00

TCI Chemical
2-Chloro-4-nitropyridine >98.0%(GC)
5g
$ 104.00

TCI Chemical
2-Chloro-4-nitropyridine >98.0%(GC)
25g
$ 325.00

TCI Chemical
2-Chloro-4-nitropyridine >98.0%(GC)
1g
$ 37.00

Sigma-Aldrich
2-Chloro-4-nitropyridine 97%
1g
$ 54.00

Sigma-Aldrich
2-Chloro-4-nitropyridine 97%
5g
$ 47.00

Medical Isotopes, Inc.
2-Chloro-4-nitropyridine 98%
10 g
$ 338.00

Matrix Scientific
2-Chloro-4-nitropyridine 98%
5g
$ 27.00

Matrix Scientific
2-Chloro-4-nitropyridine 98%
25g
$ 64.00

Matrix Scientific
2-Chloro-4-nitropyridine 98%
100g
$ 155.00

Total 143 raw suppliers

Chemical Property of 2-Chloro-4-nitropyridine

Chemical Property:

Appearance/Colour:Light yellow powder
Melting Point:52-56 °C
Boiling Point:258.4 °C at 760 mmHg
PKA:-1.93±0.10(Predicted)
Flash Point:110.1 °C
PSA：58.71000
Density:1.489 g/cm³
LogP:2.16640
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:157.9883050
Heavy Atom Count:10
Complexity:136

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-nitropyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 20/21/22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C(C=C1[N+](=O)[O-])Cl
Uses 2-Chloro-4-nitropyridine is used in the preparation of (thio)barbituric acid derivatives in the treatment of obesity related non-alcoholic fatty liver disease. As well it is used in the production of selective and potent MET Kinase inhibitors. 2-Chloro-4-nitropyridine may be used to synthesize 2-chloro-4-ethoxypyridine and 4-thiophenoxypyridines.

Technology Process of 2-Chloro-4-nitropyridine

There total 5 articles about 2-Chloro-4-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 14432-16-7
2-chloro-4-nitropyridine-N-oxide

: 23056-36-2
2-chloro-4-nitropyridine

Guidance literature:: With phosphorus trichloride; In dichloromethaneu; for 4h; Reflux;
DOI:10.1021/jo901522r

Reference yield: 60.0%

: 1124-33-0
4-nitraminopyridine N-oxide

: 23056-36-2
2-chloro-4-nitropyridine

Guidance literature:: DOI:10.1016/0040-4039(95)01582-3

Reference yield:

: 109-09-1
2-chloropyridine

: 23056-36-2
2-chloro-4-nitropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: peroxyacetic acid; acetic acid

2: concentrated sulfuric acid; nitric acid

3: phosphorus (III)-chloride; ethyl acetate

With peracetic acid; sulfuric acid; nitric acid; acetic acid; ethyl acetate; phosphorus trichloride;
DOI:10.1021/ja01520a021