2-CHLORO-4,6-DIMETHYLNICOTINAMIDE

Base Information

• Chemical Name: 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE
• CAS No.: 140413-44-1
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.625
• Hs Code.: 2933399090
• Mol file: 140413-44-1.mol

Synonyms:2-chloro-4,6-dimethylpyridine-3-carboxamide;2-chloro-4,6-dimethylpyridine-3-carboxamide;

Chemical Property of 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE

Chemical Property:

• Vapor Pressure: 0.00672mmHg at 25°C
• Melting Point: 154-155 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.569
• Boiling Point: 270.7 °C at 760 mmHg
• PKA: 14.42±0.50(Predicted)
• Flash Point: 117.5 °C
• PSA: 55.98000
• Density: 1.265 g/cm³
• LogP: 2.15100
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-4,6-dimethylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE

There total 4 articles about 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-4,6-dimethylnicotinonitrile (14237-71-9) → 2-chloro-4,6-dimethylnicotinic acid amide (140413-44-1)

Guidance literature:

With sulfuric acid; at 120 ℃; for 2h;

DOI:10.1021/jm00088a027

Reference yield:

3-cyano-4,6-dimethylpyridin-2(1H)-one → 2-chloro-4,6-dimethylnicotinic acid amide (140413-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 57.7 percent / POCl₃ / dimethylformamide / 4 h

2: 65 percent / conc. H₂SO₄ / 4 h / 70 °C

With sulfuric acid; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1007/BF00531481

Reference yield:

2-hydroxy-4,6-dimethyl-3-carbonitrile (769-28-8,70254-47-6) → 2-chloro-4,6-dimethylnicotinic acid amide (140413-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / POCl₃ / 3 h / Heating

2: 100 percent / conc. H₂SO₄ / 2 h / 120 °C

With sulfuric acid; trichlorophosphate;

DOI:10.1021/jm00088a027

upstream raw materials:

2-chloro-4,6-dimethylnicotinonitrile

3-Cyano-4,6-dimethyl-2(1H)-pyridon

2-hydroxy-4,6-dimethyl-3-carbonitrile

Downstream raw materials:

4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo<3,4-b>pyridine

3-amino-2-chloro-4,6-dimethylpyridine

N-(2-chloro-4,6-dimethyl-3-pyridyl)salicylamide

2,4,5-trimethylpyrido<2,3-b><1,4>benzoxazepin-6(5H)-one

Refernces

• 1、 Klunder, Janice M.,Hargrave, Karl D.,West, MaryAnn,Cullen, Ernest,Pal, Kollol,et al.. "Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones". . p. 1887 - 1897. Retrieved 2007/10/02.