Thiourea, N-[(1S,2S)-2-aminocyclohexyl]-N'-[(1R)-1-phenylethyl]-

Base Information

• Chemical Name: Thiourea, N-[(1S,2S)-2-aminocyclohexyl]-N'-[(1R)-1-phenylethyl]-
• CAS No.: 874662-43-8
• Molecular Formula: C15H23N3S
• Molecular Weight: 277.42800

Synonyms:1-((1S,2S)-2-NH2-cyclohexyl)-3-((R)-1-phenylethyl)thiourea;1-((1S,2S)-2-Amino-cyclohexyl)-3-((R)-1-phenyl-ethyl)-thiourea;1-[(1S,2S)-2-aminocyclohexyl]-3-[(R)-1-phenylethyl]thiourea;

Chemical Property of Thiourea, N-[(1S,2S)-2-aminocyclohexyl]-N'-[(1R)-1-phenylethyl]-

Chemical Property:

• Melting Point: 62 - 63 °C
• Boiling Point: 407.3±55.0 °C(Predicted)
• PSA: 82.17000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 3.96370

Purity/Quality:

>95%,>98%e.e. ^*data from raw suppliers

Safty Information:

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Technology Process of Thiourea, N-[(1S,2S)-2-aminocyclohexyl]-N'-[(1R)-1-phenylethyl]-

There total 2 articles about Thiourea, N-[(1S,2S)-2-aminocyclohexyl]-N'-[(1R)-1-phenylethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S,S)-1,2-diaminocyclohexane (21436-03-3) + (R)-(1-isothiocyanatoethyl)benzene (24277-44-9) → 1-((1S,2S)-2-aminocyclohexyl)-3-((R)-1-phenylethyl)thiourea (874662-43-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/b517937h

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → 1-((1S,2S)-2-aminocyclohexyl)-3-((R)-1-phenylethyl)thiourea (874662-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / DCC / diethyl ether / 15 h / -10 - 20 °C

2: 57 percent / CH₂Cl₂ / 3 h / 20 °C

With dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;

DOI:10.1002/ejoc.200500420

Reference yield: 100.0%

benzaldehyde (100-52-7) + 1-((1S,2S)-2-aminocyclohexyl)-3-((R)-1-phenylethyl)thiourea (874662-43-8) → 1-((R)-1-Phenyl-ethyl)-3-((1S,2S)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-thiourea

Guidance literature:

With sodium sulfate; In methanol; at 40 - 45 ℃; for 5h;

DOI:10.1002/ejoc.200500420

upstream raw materials:

(S,S)-1,2-diaminocyclohexane

(R)-(1-isothiocyanatoethyl)benzene

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

C₂₈H₃₆N₄O₃S

C₂₁H₃₃N₅O₂S*C₂HF₃O₂

C₁₆H₂₅N₅S

C₂₆H₄₁N₅O₄S

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