2-Chloro-4-pyrrolidinopyridine

Base Information

• Chemical Name: 2-Chloro-4-pyrrolidinopyridine
• CAS No.: 874758-84-6
• Molecular Formula: C₉H₁₁ClN₂
• Molecular Weight: 182.653
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50470375
• Mol file: 874758-84-6.mol

Synonyms:2-Chloro-4-pyrrolidinopyridine;874758-84-6;2-Chloro-4-(pyrrolidin-1-yl)pyridine;2-chloro-4-pyrrolidin-1-ylpyridine;SCHEMBL24126771;DTXSID50470375;ZJB75884;MFCD09032267;AKOS006291363;MB06828;BS-24019;CS-0456633;F70158;A862577

Chemical Property of 2-Chloro-4-pyrrolidinopyridine

Chemical Property:

• PSA: 16.13000
• LogP: 2.40020
• Storage Temp.: Room temperature.
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 182.0610761
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-4-(pyrrolidin-1-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)C2=CC(=NC=C2)Cl

Technology Process of 2-Chloro-4-pyrrolidinopyridine

There total 2 articles about 2-Chloro-4-pyrrolidinopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,4-dichloropyridine (26452-80-2) + bis(pyrrolidine)zinc(II) chloride (53293-51-9) → 2-chloro-4-(pyrrolidin-1-yl)-pyridine (874758-84-6)

Guidance literature:

In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.8b01687

Reference yield: 75.0%

4-pyrrolidin-1-ylpyridine (2456-81-7) → 2-chloro-4-(pyrrolidin-1-yl)-pyridine (874758-84-6)

Guidance literature:

4-pyrrolidin-1-ylpyridine; With n-butyllithium; 2-(N,N-dimethylamino)ethanol; In hexane; at 0 ℃; for 3h;

With hexachloroethane; In hexane; at -78 - 20 ℃;

DOI:10.1021/jo051994k

upstream raw materials:

4-pyrrolidin-1-ylpyridine

2,4-dichloropyridine

bis(pyrrolidine)zinc(II) chloride