2,4-Dichloropyridine

Base Information

• Chemical Name: 2,4-Dichloropyridine
• CAS No.: 26452-80-2
• Molecular Formula: C5H3Cl2N
• Molecular Weight: 147.992
• Hs Code.: 29333990
• European Community (EC) Number: 247-717-7
• DSSTox Substance ID: DTXSID20181047
• Nikkaji Number: J88.423E
• Wikidata: Q72467883
• Mol file: 26452-80-2.mol

Synonyms:2,4-DICHLOROPYRIDINE;26452-80-2;Pyridine, 2,4-dichloro-;2,4-dichloro pyridine;2, 4-dichloropyridine;EINECS 247-717-7;MFCD00955618;2,4-dichoropyridine;2,4-dichloro-pyridine;4-dichloropyridine;2,4-dichlorpyridin;2,4-dichlorpyridine;2,4-Dichloropyrdine;2,4-bis(chloranyl)pyridine;2,4-Dichloropyridine, 97%;SCHEMBL172300;DTXSID20181047;BCP22207;STK688595;AKOS005145611;AB07735;CS-W004774;PB47770;PS-5824;AC-24482;A5243;AM20051010;D3784;FT-0630310;EN300-43516;A818451;W-107169

Chemical Property of 2,4-Dichloropyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Vapor Pressure: 0.658mmHg at 25°C
• Melting Point: -1 °C
• Refractive Index: 1.55-1.554
• Boiling Point: 193.1 °C at 760 mmHg
• PKA: 0.12±0.10(Predicted)
• Flash Point: 88 °C
• PSA: 12.89000
• Density: 1.388 g/cm³
• LogP: 2.38840
• Storage Temp.: Refrigerator
• Solubility.: Chloroform
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 146.9642545
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xi,Xn
• Hazard Codes: T,Xi,Xn
• Statements: 25-38-41-43-36/37/38-20/22
• Safety Statements: 26-36/37/39-45-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CN=C(C=C1Cl)Cl
• Uses: 2,4-Dichloropyridine is a versatile reactant used in the preparation of host materials for light-emitting diodes with heterocyclic cores. Also used in the preparation of sulfonylated pyridines, pyrazine and quinoline via aromatic nucleophilic substitution of azines with sodium sulfinates.

Technology Process of 2,4-Dichloropyridine

There total 28 articles about 2,4-Dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-Amino-2-chloropyridine (14432-12-3) → 2,4-dichloropyridine (26452-80-2)

Guidance literature:

With pyrylium tetrafluoroborate; magnesium chloride; In acetonitrile; for 16h; Heating; Sealed tube;

DOI:10.1038/s41557-021-00812-0

Reference yield: 67.0%

2-chloro-4-iodopyridine (153034-86-7) → 2,4-dichloropyridine (26452-80-2)

Guidance literature:

2-chloro-4-iodopyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 1h;

With N-chloro-succinimide; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1002/1099-0690(200104)2001:7<1371::AID-EJOC1371>3.0.CO;2-E

Reference yield: 67.0%

2,4-dichloro-6-hydrazinopyridine (837365-03-4) → 2,4-dichloropyridine (26452-80-2)

Guidance literature:

With copper(II) sulfate; In water; for 0.75h; Heating;

DOI:10.1021/jo047962z

upstream raw materials:

2-Amino-4-chloropyridine

3-deazauracil

4-Amino-2-chloropyridine

4-nitraminopyridine N-oxide

Downstream raw materials:

2,4-dimethoxypyridine

2,4-Diethoxypyridin

2-Amino-4-chloropyridine

4-Amino-2-chloropyridine