2-[6-aMino-8-(2-iodo-5-Methoxy-phenylsulfanyl)purin-9-yl]ethanol

Base Information

• Chemical Name: 2-[6-aMino-8-(2-iodo-5-Methoxy-phenylsulfanyl)purin-9-yl]ethanol
• CAS No.: 874903-80-7
• Molecular Formula: C₁₄H₁₄IN₅O₂S
• Molecular Weight: 443.268
• Mol file: 874903-80-7.mol

Synonyms:2-[6-Amino-8-(2-iodo-5-methoxy-phenylsulfanyl)-purin-9-yl]-ethanol;

Chemical Property of 2-[6-aMino-8-(2-iodo-5-Methoxy-phenylsulfanyl)purin-9-yl]ethanol

Chemical Property:

• Melting Point: 184 - 187 °C
• PSA: 124.38000
• LogP: 2.74640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-aMino-8-(2-iodo-5-Methoxy-phenylsulfanyl)purin-9-yl]ethanol

There total 7 articles about 2-[6-aMino-8-(2-iodo-5-Methoxy-phenylsulfanyl)purin-9-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid 2-[6-amino-8-(2-iodo-5-methoxy-phenylsulfanyl)-purin-9-yl]-ethyl ester → 2-[6-amino-8-(2-iodo-5-methoxy-phenylsulfanyl)purin-9-yl]ethanol (874903-80-7)

Guidance literature:

With methanol; potassium carbonate; at 50 ℃; for 3h;

DOI:10.1021/jm0503087

Reference yield:

acetic acid 2-(6-amino-8-bromopurin-9-yl)-ethyl ester (874903-79-4) → 2-[6-amino-8-(2-iodo-5-methoxy-phenylsulfanyl)purin-9-yl]ethanol (874903-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 16 h / 50 °C

2: 9 g / K₂CO₃; MeOH / 3 h / 50 °C

With methanol; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm0503087

Reference yield:

acetic acid 2-(6-aminopurin-9-yl)-ethyl ester (5845-43-2) → 2-[6-amino-8-(2-iodo-5-methoxy-phenylsulfanyl)purin-9-yl]ethanol (874903-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 6.7 g / Br₂; aq. acetate buffer / methanol; tetrahydrofuran

2: dimethylformamide / 16 h / 50 °C

3: 9 g / K₂CO₃; MeOH / 3 h / 50 °C

With methanol; acetate buffer; bromine; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0503087

upstream raw materials:

acetic acid 2-(6-amino-8-bromopurin-9-yl)-ethyl ester

acetic acid 2-(6-aminopurin-9-yl)-ethyl ester

adenine

dithiocarbonic acid O-ethyl ester S-(2-iodo-5-methoxyphenyl)