3-Phenylspiro[isobenzofuran-1(3H),4'-piperidine]

Base Information

Chemical Name:3-Phenylspiro[isobenzofuran-1(3H),4'-piperidine]
CAS No.:59142-94-8
Molecular Formula:C₁₈H₁₉NO
Molecular Weight:265.355
Hs Code.:
Mol file:59142-94-8.mol

Synonyms:HP 505;1,3-dihydro-3-phenylspiro[isobenzofuran-1,4'-piperidine];3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine];3-phenyl-3h-spiro[2-benzofuran-1,4'-piperidine];

Suppliers and Price of 3-Phenylspiro[isobenzofuran-1(3H),4'-piperidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-Phenylspiro[isobenzofuran-1(3H),4'-piperidine]

Chemical Property:

Boiling Point:423.3°Cat760mmHg
Flash Point:174°C
PSA：21.26000
Density:1.17g/cm³
LogP:3.71370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Phenylspiro[isobenzofuran-1(3H),4'-piperidine]

There total 7 articles about 3-Phenylspiro[isobenzofuran-1(3H),4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59142-31-3
1'-benzyl-3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine]

: 59142-94-8,59143-31-6,59143-46-3
HP 505

Guidance literature:: With hydrogen; palladium on activated charcoal; In isopropyl alcohol; toluene; at 75 ℃; for 5h; under 2482.3 Torr;
DOI:10.1021/jm00233a012

Reference yield:

: 13047-06-8
o-bromobenzophenone

: 59142-94-8,59143-31-6,59143-46-3
HP 505

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / ethanol

2: HCl

3: (i) nBuLi, THF, hexane, (ii) /BRN= 106924/, (iii) aq. HCl, AcOH

4: benzene / 18 h / Heating

5: aq. NaOH / ethanol / 18 h / Heating

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; In ethanol; benzene;
DOI:10.1021/jm00233a012

Reference yield:

: 59142-71-1
1-bromo-2-[methoxy(phenyl)methyl]-benzene

: 59142-94-8,59143-31-6,59143-46-3
HP 505

Guidance literature:: Multi-step reaction with 3 steps

1: (i) nBuLi, THF, hexane, (ii) /BRN= 106924/, (iii) aq. HCl, AcOH

2: benzene / 18 h / Heating

3: aq. NaOH / ethanol / 18 h / Heating

With sodium hydroxide; In ethanol; benzene;
DOI:10.1021/jm00233a012