7-fluoro-1-Methyl-1H-Indole-2,3-dione

Base Information

• Chemical Name: 7-fluoro-1-Methyl-1H-Indole-2,3-dione
• CAS No.: 875003-43-3
• Molecular Formula: C9H6FNO2
• Molecular Weight: 179.151
• Hs Code.: 2933998090
• Mol file: 875003-43-3.mol

Synonyms:1-methyl-7-fluorolndoline-2,3-dione;7-fluoro-1-Methyl-1H-Indole-2,3-dione;7-fluoro-1-methylisatin;7-fluoro-N-methylisatin;

Chemical Property of 7-fluoro-1-Methyl-1H-Indole-2,3-dione

Chemical Property:

• PSA: 37.38000
• LogP: 1.04980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-Fluoro-1-methylindoline-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-fluoro-1-Methyl-1H-Indole-2,3-dione

There total 7 articles about 7-fluoro-1-Methyl-1H-Indole-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

7-fluoro-1H-indole-2,3-dione (317-20-4) + methyl iodide (74-88-4) → 7-fluoro-1-methyl-1H-indole-2,3-dione (875003-43-3)

Guidance literature:

With KF-Celite; In 2-methyltetrahydrofuran; for 6h; chemoselective reaction; Reflux;

DOI:10.1039/c5gc01002k

Reference yield: 70.0%

7-fluoro-1H-indole-2,3-dione (317-20-4) + dimethyl sulfate (77-78-1) → 7-fluoro-1-methyl-1H-indole-2,3-dione (875003-43-3)

Guidance literature:

With sodium carbonate; In acetone; at 60 ℃; for 20h;

DOI:10.1021/jm060314i

Reference yield:

2-Fluoroaniline (348-54-9) → 7-fluoro-1-methyl-1H-indole-2,3-dione (875003-43-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂SO₄; NH₂OH*HCl; aq. HCl / 2 h / 80 - 90 °C

2: H₂SO₄ / 0.25 h / 80 °C

3: 70 percent / Na₂CO₃ / acetone / 20 h / 60 °C

With hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; sodium carbonate; sodium sulfate; In acetone;

DOI:10.1021/jm060314i

upstream raw materials:

7-fluoro-1H-indole-2,3-dione

dimethyl sulfate

2-Fluoroaniline

N-(2-Fluorophenyl)-2-hydroxyiminoacetamide

Downstream raw materials:

C₁₅H₁₁FN₂O₂

C₃₁H₂₂FNO₄

C₃₇H₃₆FNO₄Si

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