Ethyl 8-hydroxy-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate

Base Information

• Chemical Name: Ethyl 8-hydroxy-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate
• CAS No.: 14205-65-3
• Molecular Formula: C13H11 N O5
• Molecular Weight: 261.234
• Hs Code.: 2933499090
• European Community (EC) Number: 238-060-7
• UNII: V5RH9884PQ
• DSSTox Substance ID: DTXSID5065728
• Nikkaji Number: J33.513D
• Wikidata: Q81992354
• Mol file: 14205-65-3.mol

Synonyms:14205-65-3;Ethyl 8-hydroxy-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate;ethyl 8-hydroxy[1,3]dioxolo[4,5-g]quinoline-7-carboxylate;16171-98-5;8-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLIC ACID ETHYL ESTER;ethyl 8-oxo-5H-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate;Ethyl 1,4-dihydro-6,7-methylenedioxy-4-oxoquinoline-3-carboxylate;V5RH9884PQ;1,3-Dioxolo[4,5-g]quinoline-7-carboxylic acid, 8-hydroxy-, ethyl ester;EINECS 238-060-7;MFCD00173400;1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid, 8-hydroxy-, ethyl ester;Ethyl 8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate;Ethyl 8-hydroxy-(1,3)dioxolo(4,5-g)quinoline-7-carboxylate;Ethyl 8-hydroxy-1,3-dioxolo(4,5-g)quinoline-7-carboxylate;ethyl 8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylate;UNII-V5RH9884PQ;Oprea1_523562;Oprea1_578827;SCHEMBL242405;SCHEMBL9319436;DTXSID5065728;ethyl 8-hydroxy-2H-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate;CCG-52781;AKOS005070713;SY290797;CS-0169512;FT-0637032;6J-044;E73925;A807849;J-521238;SR-01000641991-1;7,12-DIMETHYL-8,9-DIHYDROBENZO(A)ANTHRACENE-8,9-DIOL;ethyl 8-hydroxy-1,3-dioxolo[4,5-g]-quinoline-7-carboxylate;4-Hydroxy-6,7-methylenebisoxy-3-quinolinecarboxylic acid ethyl ester;4-Hydroxy-6,7-methylenedioxy-3-quinolinecarboxylic acid ethyl ester;6,7-methylenedioxy-4(1H)-quinolone-3-carboxylic acid, ethyl ester;8-HYDROXY-1,3DIOXOLO4,5-GQUINOLINE-7-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of Ethyl 8-hydroxy-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate

Chemical Property:

• Vapor Pressure: 3.71E-07mmHg at 25°C
• Melting Point: 311-313°(dec)
• Boiling Point: 416.8°Cat760mmHg
• Flash Point: 205.9°C
• PSA: 77.88000
• Density: 1.409g/cm³
• LogP: 1.84580
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 261.06372245
• Heavy Atom Count: 19
• Complexity: 433

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 8-hydroxy[1,3]dioxolo[4,5-g]quinoline-7-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CNC2=CC3=C(C=C2C1=O)OCO3

Technology Process of Ethyl 8-hydroxy-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate

There total 5 articles about Ethyl 8-hydroxy-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

diethyl [[3,4-(methylenedioxy)phenylamino]methylene]malonate (17394-77-3) → ethyl 8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylate (14205-65-3)

Guidance literature:

diethyl [[3,4-(methylenedioxy)phenylamino]methylene]malonate; In methyloxirane; at 120 ℃; for 2h;

With ammonium hydroxide; In water; pH=8;

Reference yield:

benzo[1,3]dioxolo-5-ylamine (14268-66-7) → ethyl 8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylate (14205-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / benzene / 3.5 h / Heating

2: PPE / 2 h / 120 °C

With PPE; In benzene;

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylate (14205-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / benzene / 3.5 h / Heating

2: PPE / 2 h / 120 °C

With PPE; In benzene;

upstream raw materials:

diethyl [[3,4-(methylenedioxy)phenylamino]methylene]malonate

benzo[1,3]dioxolo-5-ylamine

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

6,7-methylenedioxy-4-quinolone

8-hydroxy-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid

N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

N-(6,7-methylenedioxyquinolin-4-yl)-N-(2-N,N-dimethylaminoethyl)-2-iodo-4,5-dimethoxybenzamide