N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

Base Information

Chemical Name:N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide
CAS No.:529488-53-7
Molecular Formula:C₂₇H₃₃IN₂O₆Si
Molecular Weight:636.559
Hs Code.:

Synonyms:N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

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Chemical Property of N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

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Technology Process of N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

There total 9 articles about N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 113258-92-7
4,5-dimethoxy-2-iodobenzoyl chloride

: 529488-57-1
4-[N-[2-(t-butyldimethylsilanyloxy)]ethyl]amino-6,7-methylenedioxyquinoline

: 529488-53-7
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

Guidance literature:: With triethylamine; In dichloromethane; for 12h; Heating;
DOI:10.1016/S0968-0896(03)00051-8

Reference yield: 51.7%

: 61203-48-3
2-iodo-4,5-dimethoxybenzoic acid

: 529488-57-1
4-[N-[2-(t-butyldimethylsilanyloxy)]ethyl]amino-6,7-methylenedioxyquinoline

: 529488-53-7
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

Guidance literature:: 2-iodo-4,5-dimethoxybenzoic acid; With oxalyl dichloride; In dichloromethane; for 3h; Reflux;

4-[N-[2-(t-butyldimethylsilanyloxy)]ethyl]amino-6,7-methylenedioxyquinoline; In dichloromethane; Reflux; Inert atmosphere;

Reference yield:

: 59134-89-3
8-chloro-2H-[1,3]dioxolo[4,5-g]quinoline

: 529488-53-7
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(t-butyldimethylsilanyloxy)ethyl]-2-iodo-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenol / 2.5 h / Heating

1.2: 54 percent / phenol / 24 h / 100 °C

2.1: 48.7 percent / imidazole / dimethylformamide / 6 h / 20 °C

3.1: 52 percent / triethylamine / CH₂Cl₂ / 12 h / Heating

With 1H-imidazole; triethylamine; phenol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00051-8