1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-[(2-iodo-3-methoxyphenyl)methyl]-3-(3-methoxy phenyl)-5-(2-methylpropoxy)-, methyl ester

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-[(2-iodo-3-methoxyphenyl)methyl]-3-(3-methoxy phenyl)-5-(2-methylpropoxy)-, methyl ester
CAS No.:875152-72-0
Molecular Formula:C26H32INO6
Molecular Weight:581.448
Hs Code.:

1(2H)-Pyridinecarboxylic acid,
3,6-dihydro-3-hydroxy-2-[(2-iodo-3-methoxyphenyl)methyl]-3-(3-methoxy
phenyl)-5-(2-methylpropoxy)-, methyl ester

Synonyms:

Suppliers and Price of 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-[(2-iodo-3-methoxyphenyl)methyl]-3-(3-methoxy phenyl)-5-(2-methylpropoxy)-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-[(2-iodo-3-methoxyphenyl)methyl]-3-(3-methoxy phenyl)-5-(2-methylpropoxy)-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-[(2-iodo-3-methoxyphenyl)methyl]-3-(3-methoxy phenyl)-5-(2-methylpropoxy)-, methyl ester

There total 3 articles about 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-[(2-iodo-3-methoxyphenyl)methyl]-3-(3-methoxy phenyl)-5-(2-methylpropoxy)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 875152-62-8
2-(2-iodo-3-methoxy-benzyl)-5-isobutoxy-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 875152-72-0
3-hydroxy-2-(2-iodo-3-methoxy-benzyl)-5-isobutoxy-3-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:: With cerium(III) chloride; In tetrahydrofuran; at -15 ℃; for 2h;
DOI:10.1021/ol052262h

Reference yield:

: 3,5-dioxo-piperidine-1-carboxylic acid methyl ester

: 875152-72-0
3-hydroxy-2-(2-iodo-3-methoxy-benzyl)-5-isobutoxy-3-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7.27 g / TsOH / benzene / 4 h / Heating

2: 43 percent / LHMDS / tetrahydrofuran / -78 - -15 °C

3: 86 percent / CeCl₃ / tetrahydrofuran / 2 h / -15 °C

With cerium(III) chloride; toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; benzene;
DOI:10.1021/ol052262h

Reference yield:

: 875152-61-7
5-isobutoxy-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

: 875152-72-0
3-hydroxy-2-(2-iodo-3-methoxy-benzyl)-5-isobutoxy-3-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / LHMDS / tetrahydrofuran / -78 - -15 °C

2: 86 percent / CeCl₃ / tetrahydrofuran / 2 h / -15 °C

With cerium(III) chloride; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ol052262h