1-(1,2-Diphenylethyl)-5-ethoxypyrrolidin-2-one

Base Information

• Chemical Name: 1-(1,2-Diphenylethyl)-5-ethoxypyrrolidin-2-one
• CAS No.: 87519-71-9
• Molecular Formula: C₂₀H₂₃NO₂
• Molecular Weight: 309.408
• DSSTox Substance ID: DTXSID80527260

Synonyms:1-(1,2-Diphenylethyl)-5-ethoxypyrrolidin-2-one;87519-71-9;DTXSID80527260

Chemical Property of 1-(1,2-Diphenylethyl)-5-ethoxypyrrolidin-2-one

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 309.172878976
• Heavy Atom Count: 23
• Complexity: 372

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1CCC(=O)N1C(CC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(1,2-Diphenylethyl)-5-ethoxypyrrolidin-2-one

There total 2 articles about 1-(1,2-Diphenylethyl)-5-ethoxypyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + 1-(1,2-diphenylethyl)-2,5-pyrrolidinedione (87520-04-5) → 1-(1,2-Diphenyl-ethyl)-5-ethoxy-pyrrolidin-2-one (87519-71-9)

Guidance literature:

With sodium tetrahydroborate; methanesulfonic acid;

DOI:10.1021/jo00173a053

Reference yield:

(R,S)-1,2-diphenylethylamine (25611-78-3) → 1-(1,2-Diphenyl-ethyl)-5-ethoxy-pyrrolidin-2-one (87519-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2) acetyl chloride / 1) ethyl acetate, reflux, 30 min, 2) ethyl acetate, reflux, 10 h

2: 93 percent / NaBH₄, CH₃SO₃H

With sodium tetrahydroborate; methanesulfonic acid; acetyl chloride;

DOI:10.1021/jo00173a053

Reference yield: 83.0%

1-(1,2-Diphenyl-ethyl)-5-ethoxy-pyrrolidin-2-one (87519-71-9) → 1,5,6,10bα-tetrahydro-5α-phenylpyrrolo<2,1-a>isoquinolin-3(2H)-one (87519-72-0)

Guidance literature:

With PPA; for 1h; Ambient temperature;

DOI:10.1021/jo00173a053

upstream raw materials:

ethanol

1-(1,2-diphenylethyl)-2,5-pyrrolidinedione

(R,S)-1,2-diphenylethylamine

Downstream raw materials:

1,5,6,10bα-tetrahydro-5α-phenylpyrrolo<2,1-a>isoquinolin-3(2H)-one

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