1H-Benzimidazole-1-propanoic acid, 2,3-dihydro-2-oxo-

Base Information

• Chemical Name: 1H-Benzimidazole-1-propanoic acid, 2,3-dihydro-2-oxo-
• CAS No.: 75655-44-6
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.201
• Hs Code.: 2933990090
• Mol file: 75655-44-6.mol

Synonyms:R 40385;3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propanoic acid;

Chemical Property of 1H-Benzimidazole-1-propanoic acid, 2,3-dihydro-2-oxo-

Chemical Property:

• Refractive Index: 1.602
• PSA: 75.09000
• Density: 1.367 g/cm³
• LogP: 0.80430

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-1-propanoic acid, 2,3-dihydro-2-oxo-

There total 4 articles about 1H-Benzimidazole-1-propanoic acid, 2,3-dihydro-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(3-Isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propionic acid (104189-90-4) → 3-(1-benzimidazolonyl)propanoic acid (75655-44-6)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 6h;

DOI:10.1007/BF00515223

Reference yield: 59.0%

N-(2-aminophenyl)-β-alanine (67189-54-2) + urea (57-13-6) → 3-(1-benzimidazolonyl)propanoic acid (75655-44-6)

Guidance literature:

With hydrogenchloride; In acetic acid; for 10.5h; Heating;

DOI:10.1007/BF02253235

Reference yield:

N-(2-nitrophenyl)-β-alanine (38584-58-6) → 3-(1-benzimidazolonyl)propanoic acid (75655-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / NaOH; Na₂S₂O₄ / H₂O / 0.33 h / Heating

2: 59 percent / HCl / acetic acid / 10.5 h / Heating

With hydrogenchloride; sodium hydroxide; sodium dithionite; In water; acetic acid; 1: Hydrogenation / 2: Condensation;

DOI:10.1007/BF02253235

upstream raw materials:

3-(3-Isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propionic acid

N-(2-aminophenyl)-β-alanine

urea

N-(2-nitrophenyl)-β-alanine