3-(2,7-Dimethoxyacridin-9-ylthio)propan-1-amine

Base Information

• Chemical Name: 3-(2,7-Dimethoxyacridin-9-ylthio)propan-1-amine
• CAS No.: 184582-62-5
• Molecular Formula: C18H20N2O2S
• Molecular Weight: 328.43
• Hs Code.: 2922290090
• ChEMBL ID: CHEMBL5095897
• Mol file: 184582-62-5.mol

Synonyms:184582-62-5;LDN-192960;3-(2,7-dimethoxyacridin-9-ylthio)propan-1-amine;3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine;CCRIS 8174;3-((2,7-Dimethoxyacridin-9-yl)thio)propan-1-amine;MFCD02752814;2,7-Dimethoxy-9-(3'-aminopropyl)thioacridine;3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine;2,7-Dimethoxy-9-(3-aminopropyl)thioacridine;SCHEMBL2550572;CHEMBL5095897;HMS3749C15;BCP06879;EX-A4806;LDN192960;s3406;AKOS025149448;CS-7964;NCGC00402289-04;AC-35777;HY-13455;SY263538;F18333

Chemical Property of 3-(2,7-Dimethoxyacridin-9-ylthio)propan-1-amine

Chemical Property:

• Boiling Point: 536.1±40.0 °C(Predicted)
• PKA: 9.33±0.10(Predicted)
• PSA: 82.67000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 4.54640
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble20mg/mL, clear
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 328.12454906
• Heavy Atom Count: 23
• Complexity: 343

Purity/Quality:

99% ^*data from raw suppliers

3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N=C3C=CC(=CC3=C2SCCCN)OC
• Uses: 3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamine Hydrochloride, is an acridine analog, acting as haspin and DYRK2 kinase inhibitor. The studies has also shown that they can have antitrypanosomal and antiplasmid properties.

Technology Process of 3-(2,7-Dimethoxyacridin-9-ylthio)propan-1-amine

There total 5 articles about 3-(2,7-Dimethoxyacridin-9-ylthio)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H12NO3 + 3-bromopropylamine hydrochloride (5003-71-4) → LDN-192960 (184582-62-5)

Guidance literature:

C₁₅H₁₂NO₃; With Lawessons reagent; In tetrahydrofuran; at 110 ℃; microwave irradiation;

3-bromopropylamine hydrochloride; With phenol; at 80 ℃;

Reference yield:

C23H28N2O4S → LDN-192960 (184582-62-5)

Guidance literature:

With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.bmcl.2010.04.150

Reference yield:

4-methoxy-aniline (104-94-9) → LDN-192960 (184582-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / copper / pentan-1-ol / 110 °C

2.1: polyphosphoric acid / 110 °C

3.1: Lawessons reagent / tetrahydrofuran / 110 °C / microwave irradiation

3.2: 80 °C

With Lawessons reagent; potassium carbonate; copper; In tetrahydrofuran; pentan-1-ol;

upstream raw materials:

3-bromopropylamine hydrochloride

4-methoxy-aniline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 184582-62-5 LDN-192960

Send

Send

Metric Ton KG G Pound L ML

Send

Send