4-(Phenylsulfonyl)morpholine

Base Information

• Chemical Name: 4-(Phenylsulfonyl)morpholine
• CAS No.: 5033-21-6
• Molecular Formula: C10H13NO3S
• Molecular Weight: 227.284
• Hs Code.: 2934999090
• NSC Number: 14840
• DSSTox Substance ID: DTXSID30198343
• Nikkaji Number: J1.047.774C
• Wikidata: Q83071101
• ChEMBL ID: CHEMBL1531729
• Mol file: 5033-21-6.mol

Synonyms:4-(Phenylsulfonyl)morpholine;5033-21-6;4-(benzenesulfonyl)morpholine;4-Benzenesulfonylmorpholine;Morpholine, 4-(phenylsulfonyl)-;N-Morpholinobenzenesulfonamide;BRN 0205459;AI3-30017;4-27-00-00615 (Beilstein Handbook Reference);Morpholino phenyl sulfone;NSC14840;CBMicro_005006;Cambridge id 5112616;MLS000530147;SCHEMBL5960399;4-(Phenylsulfonyl)morpholine #;CHEMBL1531729;DTXSID30198343;HMS2368J12;SMSF0003388;MFCD00447613;NSC 14840;NSC-14840;STK980452;AKOS001592734;AM87011;CB07033;NCGC00181897-01;LS-93301;SMR000135125;BIM-0004918.P001;CS-0270217;EU-0000551;N10210;AB00005586-01;A903504;Z45515785

Chemical Property of 4-(Phenylsulfonyl)morpholine

Chemical Property:

• Vapor Pressure: 7.67E-06mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 375.6 °C at 760 mmHg
• Flash Point: 181 °C
• PSA: 54.99000
• Density: 1.292 g/cm³
• LogP: 1.72620
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 227.06161445
• Heavy Atom Count: 15
• Complexity: 284

Purity/Quality:

99%, ^*data from raw suppliers

4-(phenylsulfonyl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1S(=O)(=O)C2=CC=CC=C2

Technology Process of 4-(Phenylsulfonyl)morpholine

There total 46 articles about 4-(Phenylsulfonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + benzenesulfonyl chloride (98-09-9) → 4-benzenesulfonylmorpholine (5033-21-6)

Guidance literature:

With sodium hydroxide; In water; at 25 ℃; pH=9.15;

DOI:10.1139/v05-154

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + sodium benzenesulfonate (873-55-2) → 4-benzenesulfonylmorpholine (5033-21-6)

Guidance literature:

With iodine; In 1,2-dichloro-ethane; at 25 ℃; for 20h;

DOI:10.1002/adsc.201400801

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + S-Phenyl benzenethiosulfonate (1212-08-4) → 4-benzenesulfonylmorpholine (5033-21-6)

Guidance literature:

With N-Bromosuccinimide; caesium carbonate; In ethanol; at 80 ℃; for 16h; Reagent/catalyst; Solvent; Sealed tube;

upstream raw materials:

morpholine

benzenesulfonyl chloride

N-benzenesulfonyl-bis(2-hydroxyethyl)amine

sodium benzenesulfonate

Downstream raw materials:

morpholine

Refernces

• 1、 Spillier, Quentin,Ravez, Séverine,Unterlass, Judith,Corbet, Cyril,Degavre, Charline,Feron, Olivier,Frédérick, Rapha?l. "Structure–activity relationships (SARs) of α- ketothioamides as inhibitors of phosphoglycerate dehydrogenase (PHGDH)". . . Retrieved 2020/02/11.
• 2、 Lee, Ji-Woong,Roy, Tamal. "Cyanide-Mediated Synthesis of Sulfones and Sulfonamides from Vinyl Sulfones". . p. 455 - 458. Retrieved 2020/03/13.