2-(4-Hydroxyphenyl)-N,N-di-n-propylcyclopropylamine

Base Information

Chemical Name:2-(4-Hydroxyphenyl)-N,N-di-n-propylcyclopropylamine
CAS No.:110826-39-6
Molecular Formula:C₁₅H₂₃NO
Molecular Weight:233.354
Hs Code.:
DSSTox Substance ID:DTXSID30149395
Wikidata:Q83015162
Mol file:110826-39-6.mol

Synonyms:2-(4-hydroxyphenyl)-N,N-di-n-propylcyclopropylamine;4-OH-DPCA

Suppliers and Price of 2-(4-Hydroxyphenyl)-N,N-di-n-propylcyclopropylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-(4-Hydroxyphenyl)-N,N-di-n-propylcyclopropylamine

Chemical Property:

Vapor Pressure:1.61E-05mmHg at 25°C
Boiling Point:354.7°Cat760mmHg
PKA:10.18±0.15(Predicted)
Flash Point:160.5°C
PSA：23.47000
Density:1.04g/cm³
LogP:3.37010
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:233.177964357
Heavy Atom Count:17
Complexity:217

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN(CCC)C1CC1C2=CC=C(C=C2)O
Isomeric SMILES:CCCN(CCC)[C@@H]1C[C@H]1C2=CC=C(C=C2)O

Technology Process of 2-(4-Hydroxyphenyl)-N,N-di-n-propylcyclopropylamine

There total 5 articles about 2-(4-Hydroxyphenyl)-N,N-di-n-propylcyclopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: [(1S,2R)-2-(4-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine; hydrochloride

: 110826-22-7,110826-39-6
4-((1R,2S)-2-Dipropylamino-cyclopropyl)-phenol

Guidance literature:: With hydrogen bromide; at 110 ℃; for 2h;
DOI:10.1021/jm00396a014

Reference yield:

: N-{2-[4-(tert-butyldimethylsilanyloxy)phenyl]cyclopropyl}-N,N-dipropylamine

: 110826-39-6
4-[2-(dipropylamino)cyclopropyl]phenol

Guidance literature:: With 4 A molecular sieve; tetrabutyl-ammonium chloride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol0705907

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 110826-39-6
4-[2-(dipropylamino)cyclopropyl]phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyl lithium / tetrahydrofuran / 0.25 h

1.2: tetrahydrofuran

2.1: 31 percent / chlorotitanium triisopropoxide; cyclopentylmagnesium bromide / tetrahydrofuran

3.1: tetrabutylammonium chloride; molecular sieves 4 Angstroem / tetrahydrofuran / 0 - 20 °C

With triisopropoxytitanium(IV) chloride; n-butyllithium; 4 A molecular sieve; tetrabutyl-ammonium chloride; cyclopentylmagnesium bromide; In tetrahydrofuran; 1.2: Wittig olefination / 2.1: Kulinkovich cyclopropanation;
DOI:10.1021/ol0705907