Acetic acid, [3-methoxy-4-[(1E)-2-(1,2,3,6-tetrahydro-1,3-dimethyl-5-nitro-2,6-dioxo- 4-pyrimidinyl)ethenyl]phenoxy]-

Base Information

• Chemical Name: Acetic acid, [3-methoxy-4-[(1E)-2-(1,2,3,6-tetrahydro-1,3-dimethyl-5-nitro-2,6-dioxo- 4-pyrimidinyl)ethenyl]phenoxy]-
• CAS No.: 875802-07-6
• Molecular Formula: C17H17N3O8
• Molecular Weight: 391.337
• Mol file: 875802-07-6.mol

Synonyms:

Chemical Property of Acetic acid, [3-methoxy-4-[(1E)-2-(1,2,3,6-tetrahydro-1,3-dimethyl-5-nitro-2,6-dioxo- 4-pyrimidinyl)ethenyl]phenoxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid, [3-methoxy-4-[(1E)-2-(1,2,3,6-tetrahydro-1,3-dimethyl-5-nitro-2,6-dioxo- 4-pyrimidinyl)ethenyl]phenoxy]-

There total 1 articles about Acetic acid, [3-methoxy-4-[(1E)-2-(1,2,3,6-tetrahydro-1,3-dimethyl-5-nitro-2,6-dioxo- 4-pyrimidinyl)ethenyl]phenoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-4-carboxymethoxybenzaldehyde (84969-24-4) + 1,3,6-trimethyl-5-nitrouracil (55326-07-3) → {4-[(E)-2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-3-methoxy-phenoxy}-acetic acid (875802-07-6)

Guidance literature:

With piperidine; In 1,4-dioxane; Heating;

DOI:10.1021/jm0506221

Reference yield: 98.0%

{4-[(E)-2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-3-methoxy-phenoxy}-acetic acid (875802-07-6) → 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid (480994-24-9)

Guidance literature:

With triethyl phosphite; for 7h; Heating;

DOI:10.1021/jm0506221

Reference yield:

{4-[(E)-2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-3-methoxy-phenoxy}-acetic acid (875802-07-6) → N-(4-chloro-benzyl)-2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxy-phenoxy]-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / P(OEt)3 / 7 h / Heating

2: 61 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; polymer-bound morpholine / dimethylformamide / 20 °C

With polymer-bound morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethyl phosphite; In N,N-dimethyl-formamide;

DOI:10.1021/jm0506221

upstream raw materials:

2-methoxy-4-carboxymethoxybenzaldehyde

1,3,6-trimethyl-5-nitrouracil

Downstream raw materials:

2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid