2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid

Base Information

• Chemical Name: 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid
• CAS No.: 480994-24-9
• Molecular Formula: C₁₇H₁₇N₃O₆
• Molecular Weight: 359.338
• Mol file: 480994-24-9.mol

Synonyms:2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid

Chemical Property of 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid

There total 4 articles about 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

{4-[(E)-2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-3-methoxy-phenoxy}-acetic acid (875802-07-6) → 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid (480994-24-9)

Guidance literature:

With triethyl phosphite; for 7h; Heating;

DOI:10.1021/jm0506221

Reference yield: 77.0%

ethyl 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetate (480994-25-0) → 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid (480994-24-9)

Guidance literature:

ethyl 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetate; With water; sodium hydroxide; In ethanol; for 1h; Reflux; Inert atmosphere;

With hydrogenchloride; In ethanol; water; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.03.011

Reference yield:

2-methoxy-4-carboxymethoxybenzaldehyde (84969-24-4) → 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetic acid (480994-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dioxane / Heating

2: 98 percent / P(OEt)3 / 7 h / Heating

With piperidine; triethyl phosphite; In 1,4-dioxane;

DOI:10.1021/jm0506221

upstream raw materials:

{4-[(E)-2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-3-methoxy-phenoxy}-acetic acid

2-methoxy-4-carboxymethoxybenzaldehyde

1,3,6-trimethyl-5-nitrouracil

ethyl 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenyloxy]acetate

Downstream raw materials:

C₂₈H₃₀N₄O₅

C₂₇H₂₉N₅O₅

C₂₈H₃₁N₅O₆