Imidazo[1,2-a]pyrazine-2-carbonitrile

Base Information

• Chemical Name: Imidazo[1,2-a]pyrazine-2-carbonitrile
• CAS No.: 87597-31-7
• Molecular Formula: C₇H₄N₄
• Molecular Weight: 144.136
• Hs Code.: 2933990090
• ChEMBL ID: CHEMBL302590
• DSSTox Substance ID: DTXSID30540424
• Wikidata: Q82416434
• Mol file: 87597-31-7.mol

Synonyms:Imidazo[1,2-a]pyrazine-2-carbonitrile;87597-31-7;CHEMBL302590;SCHEMBL6369202;DTXSID30540424;AKOS006307555

Chemical Property of Imidazo[1,2-a]pyrazine-2-carbonitrile

Chemical Property:

• PSA: 53.98000
• Density: 1.37g/cm3
• LogP: 0.60098
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 144.043596145
• Heavy Atom Count: 11
• Complexity: 194

Purity/Quality:

98%min ^*data from raw suppliers

Imidazo[1,2-a]pyrazine-2-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CN2C=C(N=C2C=N1)C#N

Technology Process of Imidazo[1,2-a]pyrazine-2-carbonitrile

There total 2 articles about Imidazo[1,2-a]pyrazine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

imidazo <1,2-a>pyrazine-2-carboxamide (77124-59-5) → imidazo<1,2-a>pyrazinecarbonitrile-2 (87597-31-7)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

Reference yield:

ethyl imidazo[1,2-a]pyrazine-2-carboxylate (77112-52-8) → imidazo<1,2-a>pyrazinecarbonitrile-2 (87597-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / concd. aq. NH₄OH / 1 h / Heating

2: 78 percent / POCl₃ / 1 h / Heating

With ammonium hydroxide; trichlorophosphate;

DOI:10.1021/jm00368a018

Reference yield:

imidazo<1,2-a>pyrazinecarbonitrile-2 (87597-31-7) → C14H11N7O2 (89331-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / hydrate d'hydrazine / ethanol / 3 h / Heating

2: 95 percent / ethanol

With hydrazine hydrate; In ethanol;

upstream raw materials:

imidazo <1,2-a>pyrazine-2-carboxamide

ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Downstream raw materials:

C₁₄H₁₂N₆

C₁₃H₁₆N₆

C₁₅H₁₄N₆O

C₁₅H₁₄N₆O

Refernces

• 1、 Bonnet,Sablayrolles,Chapat,et al.. "Imidazo[1,2-a]pyrazine-2 carboxyamidrazones: Synthesis and antibacterial activity". . p. 413 - 417. Retrieved 2007/10/02.