5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline

Base Information

Chemical Name:5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline
CAS No.:83148-65-6
Molecular Formula:C25H28N2O5
Molecular Weight:436.5002
Hs Code.:
Mol file:83148-65-6.mol

Synonyms:

Suppliers and Price of 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline

Chemical Property:

Vapor Pressure:1.64E-22mmHg at 25°C
Boiling Point:732.3°Cat760mmHg
Flash Point:396.7°C
PSA：103.78000
Density:1.25g/cm³
LogP:3.02740

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline

There total 12 articles about 5-benzamido-2-methyl-4-oxo-6-phenylhexanoylproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22644-27-5
(R)-methylsuccinic acid dimethyl ester

: 83148-65-6
(S)-1-((2R,5S)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

2: pyridine, HOAc / 1 h / 100 °C

3: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature

4: 1-hydroxybenzotriazole hydrate, Et₃N, DCC / CH₂Cl₂ / 20 h / Ambient temperature

5: H₂ / Pd/C

With pyridine; sodium hydroxide; hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00353a005

Reference yield:

: 498-21-5,636-60-2
2-methylbutanedioic acid

: 83148-65-6
(S)-1-((2R,5S)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

2: 49.4 percent / 10percent aq. NaOH / diethyl ether / 0 °C

4: pyridine, HOAc / 1 h / 100 °C

5: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature

6: 1-hydroxybenzotriazole hydrate, Et₃N, DCC / CH₂Cl₂ / 20 h / Ambient temperature

7: H₂ / Pd/C

With pyridine; sodium hydroxide; hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00353a005

Reference yield:

: 3641-51-8
2-(R)-methylsuccinic acid

: 83148-65-6
(S)-1-((2R,5S)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 49.4 percent / 10percent aq. NaOH / diethyl ether / 0 °C

3: pyridine, HOAc / 1 h / 100 °C

4: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature

5: 1-hydroxybenzotriazole hydrate, Et₃N, DCC / CH₂Cl₂ / 20 h / Ambient temperature

6: H₂ / Pd/C

With pyridine; sodium hydroxide; hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00353a005