1H-Pyrazolo[4,3-c]pyridine,1-ethyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydro-5-(phenylmethyl)-,monomethanesulfonate

Base Information

Chemical Name:1H-Pyrazolo[4,3-c]pyridine,1-ethyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydro-5-(phenylmethyl)-,monomethanesulfonate
CAS No.:87629-61-6
Molecular Formula:C21H22FN3.CH4O3S
Molecular Weight:335.424
Hs Code.:

Synonyms:

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Chemical Property of 1H-Pyrazolo[4,3-c]pyridine,1-ethyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydro-5-(phenylmethyl)-,monomethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[4,3-c]pyridine,1-ethyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydro-5-(phenylmethyl)-,monomethanesulfonate

There total 6 articles about 1H-Pyrazolo[4,3-c]pyridine,1-ethyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydro-5-(phenylmethyl)-,monomethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 87629-18-3
1-Ethyl-3-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 87629-61-6
5-Benzyl-1-ethyl-3-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: With potassium carbonate; potassium iodide; In butanone; for 24h; Heating;
DOI:10.1021/jm00145a015

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 87629-61-6
5-Benzyl-1-ethyl-3-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: p-toluenesulfonic acid / benzene / 8 h / Heating

2: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

3: 98percent hydrazine hydrate / aq. ethanol / 3 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 2 h

5: 71 percent / 10percent aq.HCl / ethanol / 2 h / Heating

6: 69 percent / potassium iodide, potassium carbonate / butan-2-one / 24 h / Heating

With hydrogenchloride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; potassium iodide; In ethanol; dichloromethane; butanone; benzene;
DOI:10.1021/jm00145a015

Reference yield:

: 55459-60-4
1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone

: 87629-61-6
5-Benzyl-1-ethyl-3-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

2: 98percent hydrazine hydrate / aq. ethanol / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 50 deg C, 2 h

4: 71 percent / 10percent aq.HCl / ethanol / 2 h / Heating

5: 69 percent / potassium iodide, potassium carbonate / butan-2-one / 24 h / Heating

With hydrogenchloride; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; potassium iodide; In ethanol; dichloromethane; butanone;
DOI:10.1021/jm00145a015