4-Piperidinone, 1-acetyl-3-(4-fluorobenzoyl)-

Base Information

• Chemical Name: 4-Piperidinone, 1-acetyl-3-(4-fluorobenzoyl)-
• CAS No.: 87642-26-0
• Molecular Formula: C₁₄H₁₄FNO₃
• Molecular Weight: 263.268
• DSSTox Substance ID: DTXSID50437281

Synonyms:4-Piperidinone, 1-acetyl-3-(4-fluorobenzoyl)-;87642-26-0;SCHEMBL10800533;DTXSID50437281

Chemical Property of 4-Piperidinone, 1-acetyl-3-(4-fluorobenzoyl)-

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 263.09577147
• Heavy Atom Count: 19
• Complexity: 388

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N1CCC(=O)C(C1)C(=O)C2=CC=C(C=C2)F

Technology Process of 4-Piperidinone, 1-acetyl-3-(4-fluorobenzoyl)-

There total 3 articles about 4-Piperidinone, 1-acetyl-3-(4-fluorobenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-acetyl-4-piperidinone (32161-06-1) → 1-Acetyl-3-(4-fluoro-benzoyl)-piperidin-4-one (87642-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / benzene / 8 h / Heating

2: triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

With toluene-4-sulfonic acid; triethylamine; In dichloromethane; benzene;

DOI:10.1021/jm00145a015

Reference yield:

4-fluorobenzoyl chloride (403-43-0) + 1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone (55459-60-4) → 1-Acetyl-3-(4-fluoro-benzoyl)-piperidin-4-one (87642-26-0)

Guidance literature:

With triethylamine; In dichloromethane; for 20h; Ambient temperature;

DOI:10.1021/jm00145a015

Reference yield:

1-[5-(4-Fluoro-benzoyl)-4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl]-ethanone (144507-34-6) → 1-Acetyl-3-(4-fluoro-benzoyl)-piperidin-4-one (87642-26-0)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 0.5h; Yield given; Ambient temperature;

DOI:10.1016/0223-5234(92)90085-F

upstream raw materials:

4-fluorobenzoyl chloride

1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone

1-[5-(4-Fluoro-benzoyl)-4-morpholin-4-yl-3,6-dihydro-2H-pyridin-1-yl]-ethanone

1-acetyl-4-piperidinone

Downstream raw materials:

1-Acetyl-3-[1-(4-fluoro-phenyl)-1-pyrrolidin-1-yl-meth-(Z)-ylidene]-piperidin-4-one

5-acetyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo<4,3-c>pyridine

3-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo<4,3-c>pyridine

3-(4-Fluoro-phenyl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

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