1-(2-Hydroxyethyl)-eta-caprolactam

Base Information

• Chemical Name: 1-(2-Hydroxyethyl)-eta-caprolactam
• CAS No.: 45889-43-8
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.213
• Hs Code.: 2933790090
• Mol file: 45889-43-8.mol

Synonyms:Hydroxyethylcaprolactam

Chemical Property of 1-(2-Hydroxyethyl)-eta-caprolactam

Chemical Property:

• Vapor Pressure: 2.41E-05mmHg at 25°C
• Boiling Point: 321.3°Cat760mmHg
• Flash Point: 148.1°C
• PSA: 40.54000
• Density: 1.07g/cm³
• LogP: 0.31920

Purity/Quality:

99%min ^*data from raw suppliers

1-(2-hydroxyethyl)azepan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Hydroxyethyl)-eta-caprolactam

There total 3 articles about 1-(2-Hydroxyethyl)-eta-caprolactam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C8H14NO(1+)*BF4(1-) → 1-(2'-hydroxyethyl)azepan-2-one (45889-43-8)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jo951953w

Reference yield: 98.0%

2-azidoethanol (1517-05-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(2'-hydroxyethyl)azepan-2-one (45889-43-8)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; for 3h;

DOI:10.1021/ja00135a036

Reference yield:

→ 1-(2'-hydroxyethyl)azepan-2-one (45889-43-8)

Guidance literature:

2-Oxo-hexahydro-1H-azepin 1. Natrium in abs. Xylol, 20grad, 12 h 2. 2-Chlorethanol, 120-125grad;

upstream raw materials:

2-azidoethanol

cyclohexanone

Refernces

• 1、 Forsee, Jennifer E.,Aube, Jeffrey. "Hydrolysis of iminium ethers derived from the reaction of ketones with hydroxy azides: Synthesis of macrocyclic lactams and lactones". . p. 4381 - 4385. Retrieved 2007/10/03.
• 2、 Gracias, Vijaya,Milligan, Gregory L.,Aube, Jeffrey. "Synthesis of functionalized N-alkyl heterocycles from ketones by a sequential ring expansion/nucleophilic addition process". . p. 10 - 11. Retrieved 2007/10/03.