2-Azidoethanol

Base Information

• Chemical Name: 2-Azidoethanol
• CAS No.: 1517-05-1
• Molecular Formula: C2H5 N3 O
• Molecular Weight: 87.0812
• Hs Code.: 2929909090
• European Community (EC) Number: 808-606-4
• UNII: D96992S9O1
• DSSTox Substance ID: DTXSID20164850
• Nikkaji Number: J80.218B
• Wikidata: Q27276260
• Mol file: 1517-05-1.mol

Synonyms:2-Azidoethanol;1517-05-1;Ethanol, 2-azido-;2-azidoethan-1-ol;Azido-PEG1;2-azido-ethanol;1517-14-2;MFCD01940545;D96992S9O1;CCRIS 4996;2azidoethanol;2-Azidoethanole;UNII-D96992S9O1;Azido-PEG1-alcohol;2-Hydroxyethyl azide;AZIDOETHANOL, 2-;LCZC1122;DTXSID20164850;BSULWPSUVMOMAN-UHFFFAOYSA-N;2-Azido-ethanole, 20 wt% in DCM;2-Azidoethanole, 20 wt% in toluene;AKOS010631284;HY-138461;BB 0305512;CS-0148425;EN300-54800;A902274;Q27276260;F8880-1311

Chemical Property of 2-Azidoethanol

Chemical Property:

• Refractive Index: 1.4264 (estimate)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 69.98000
• Density: g/cm³
• LogP: -0.25824
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 87.043261792
• Heavy Atom Count: 6
• Complexity: 65.2

Purity/Quality:

98%Min ^*data from raw suppliers

2-Azidoethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CO)N=[N+]=[N-]
• Uses: 2-Azidoethanol is used as a reagent in the glycosylation of mono- or polysaccharides. 2-Azidoethanol is also used as a 2’-deoxy-ethynyluridine (EdU) blocker in nuclear DNA, preventing cross reactivity with other antibodies in order to better study its related pathways in the body.

Technology Process of 2-Azidoethanol

There total 6 articles about 2-Azidoethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromoethanol (540-51-2) → 2-azidoethanol (1517-05-1)

Guidance literature:

With sodium azide; In water; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115580

Reference yield: 99.0%

2-chloro-ethanol (107-07-3) → 2-azidoethanol (1517-05-1)

Guidance literature:

With sodium azide; tetrabutylammomium bromide; In methanol; at 110 ℃; for 18h;

DOI:10.1021/ac102781u

Reference yield: 96.0%

2-hydroxyethyl 4-methylbenzenesulfonate (42772-85-0) → 2-azidoethanol (1517-05-1)

Guidance literature:

With sodium azide; In ethanol; at 70 ℃;

DOI:10.1155/2020/6393428

upstream raw materials:

2-chloro-ethanol

2-bromoethanol

1-bromoethanol

ethanolamine

Downstream raw materials:

C₁₀H₁₃N₃O₂

2-(((1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-((1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl)methoxy)cyclohe-xyl)oxy)-1-(piperidin-1-yl)ethanone

2-(4-(4-aminophenyl)-1H-[1,2,3]-triazol-1-yl)ethanol

9-benzyl-2-azidoethoxyadenine

Refernces

• 1、 Edwards, Alyn C.,Mocilac, Pavle,Geist, Andreas,Harwood, Laurence M.,Sharrad, Clint A.,Burton, Neil A.,Whitehead, Roger C.,Denecke, Melissa A.. "Hydrophilic 2,9-bis-triazolyl-1,10-phenanthroline ligands enable selective Am(III) separation: A step further towards sustainable nuclear energy". . p. 5001 - 5004. Retrieved 2017.
• 2、 Zhang, Xiaoru,Xu, Yunpeng,Yang, Yanqiang,Jin, Xia,Ye, Sujuan,Zhang, Shusheng,Jiang, Lilin. "A new signal-on photoelectrochemical biosensor based on a graphene/quantum-dot nanocomposite amplified by the dual-quenched effect of bipyridinium relay and AuNPs". . p. 16411 - 16418. Retrieved 2012.
• 3、 Pfaendler, Hans Rudolf,Weimar, Volker. "Synthesis of racemic ethanolamine plasmalogen". . p. 1345 - 1349. Retrieved 1996.
• 4、 Sallouh, Omar,Weberskirch, Ralf. "Facile formation of hydrogels by using functional precursor polymers and the chemoselective Staudinger coupling". . p. 189 - 196. Retrieved 2016.
• 5、 Beghdadi, Samir,Abdelhedi Miladi, Imen,Ben Romdhane, Hatem,Bernard, Julien,Drockenmuller, Eric. "RAFT polymerization of bio-based 1-vinyl-4-dianhydrohexitol-1,2,3-triazole stereoisomers obtained via click chemistry". . p. 4138 - 4145. Retrieved 2012.
• 6、 Sen, Rickdeb,Gahtory, Digvijay,Carvalho, Rui Rijo,Albada, Bauke,van Delft, Floris L.,Zuilhof, Han. "Ultrathin Covalently Bound Organic Layers on Mica: Formation of Atomically Flat Biofunctionalizable Surfaces". . p. 4130 - 4134. Retrieved 2017.
• 7、 Koo, Mo Beom,Lee, Seul Woo,Lee, Jung Min,Kim, Kyoung Taek. "Iterative Convergent Synthesis of Large Cyclic Polymers and Block Copolymers with Discrete Molecular Weights". . p. 14028 - 14032. Retrieved 2020.
• 8、 Gahtory, Digvijay,Sen, Rickdeb,Pujari, Sidharam,Li, Suhua,Zheng, Qinheng,Moses, John E.,Sharpless, K. Barry,Zuilhof, Han. "Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms". . p. 10550 - 10556. Retrieved 2018.
• 9、 Piras, Monica,Testa, Andrea,Fleming, Ian N.,Dall'Angelo, Sergio,Andriu, Alexandra,Menta, Sergio,Mori, Mattia,Brown, Gavin D.,Forster, Duncan,Williams, Kaye J.,Zanda, Matteo. "High-Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin". . p. 1142 - 1151. Retrieved 2017.
• 10、 Sykam, Kesavarao,Donempudi, Shailaja. "Novel multifunctional hybrid diallyl ether monomer via azide alkyne click reaction as crosslinking agent in protective coatings". . p. 60 - 69. Retrieved 2015.