4-Acetyl-1-(2-phenylethyl)piperazine-2,6-dione

Base Information

Chemical Name:4-Acetyl-1-(2-phenylethyl)piperazine-2,6-dione
CAS No.:87693-77-4
Molecular Formula:C14H16N2O3
Molecular Weight:260.293
Hs Code.:
DSSTox Substance ID:DTXSID20516971
Wikidata:Q82378661

Synonyms:4-Acetyl-1-(2-phenylethyl)piperazine-2,6-dione;87693-77-4;SCHEMBL10968602;DTXSID20516971

Suppliers and Price of 4-Acetyl-1-(2-phenylethyl)piperazine-2,6-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-Acetyl-1-(2-phenylethyl)piperazine-2,6-dione

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:260.11609238
Heavy Atom Count:19
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CC(=O)N(C(=O)C1)CCC2=CC=CC=C2

Technology Process of 4-Acetyl-1-(2-phenylethyl)piperazine-2,6-dione

There total 2 articles about 4-Acetyl-1-(2-phenylethyl)piperazine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35975-27-0
4-acetyl-piperazine-2,6-dione

: 103-63-9
1-phenyl-2-bromoethane

: 87693-77-4
4-acetyl-2,6-dioxo-1-phenethyl piperazine

Guidance literature:: With sodium methylate; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 35975-27-0
4-acetyl-piperazine-2,6-dione

: 17376-04-4
2-phenethyl iodide

: 87693-77-4
4-acetyl-2,6-dioxo-1-phenethyl piperazine

Guidance literature:: With sodium methylate; Yield given. Multistep reaction; 1.) DMF, RT, 1 h, 2.) DMF, 120 deg C, 6 h;

Reference yield:

: 87693-77-4
4-acetyl-2,6-dioxo-1-phenethyl piperazine

: 55268-74-1,135526-78-2,57452-31-0,57452-98-9
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CuCl₂*2H₂O, 2.) NaBH₄ / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, 0 deg C 45 min.

2: 94 percent / 12N HCl / 0 °C

3: 1N HCl / 3 h / Heating

4: 90 percent / Et₃N / 1,2-dimethoxy-ethane / 15 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; triethylamine; In 1,2-dimethoxyethane;