4-Acetyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

Base Information

Chemical Name:4-Acetyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one
CAS No.:87693-79-6
Molecular Formula:C14H18N2O3
Molecular Weight:262.309
Hs Code.:
DSSTox Substance ID:DTXSID40516973

Synonyms:87693-79-6;4-Acetyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one;DTXSID40516973

Suppliers and Price of 4-Acetyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Acetyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:262.13174244
Heavy Atom Count:19
Complexity:340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CC(N(C(=O)C1)CCC2=CC=CC=C2)O

Technology Process of 4-Acetyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

There total 4 articles about 4-Acetyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87693-77-4
4-acetyl-2,6-dioxo-1-phenethyl piperazine

: 87693-79-6
1-(2-phenyl)ethyl-4-acetyl-2-hydroxypiperazine-6-one

Guidance literature:: With sodium tetrahydroborate; Yield given. Multistep reaction; 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, 0 deg C 45 min.;

Reference yield:

: 35975-27-0
4-acetyl-piperazine-2,6-dione

: 87693-79-6
1-(2-phenyl)ethyl-4-acetyl-2-hydroxypiperazine-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CH₃ONa / 1.) DMF, RT, 1 h, 2.) DMF, 120 deg C, 6 h

2: 1.) CuCl₂*2H₂O, 2.) NaBH₄ / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, 0 deg C 45 min.

With sodium tetrahydroborate; sodium methylate;

Reference yield:

: 17376-04-4
2-phenethyl iodide

: 87693-79-6
1-(2-phenyl)ethyl-4-acetyl-2-hydroxypiperazine-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CH₃ONa / 1.) DMF, RT, 1 h, 2.) DMF, 120 deg C, 6 h

2: 1.) CuCl₂*2H₂O, 2.) NaBH₄ / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, 0 deg C 45 min.

With sodium tetrahydroborate; sodium methylate;