[2-(Pyrrolidin-1-yl)phenyl]acetonitrile

Base Information

Chemical Name:[2-(Pyrrolidin-1-yl)phenyl]acetonitrile
CAS No.:87698-85-9
Molecular Formula:C12H14N2
Molecular Weight:186.257
Hs Code.:
DSSTox Substance ID:DTXSID60524292
Wikidata:Q82391045

Synonyms:87698-85-9;2-(2-(Pyrrolidin-1-yl)phenyl)acetonitrile;2-[2-(PYRROLIDIN-1-YL)PHENYL]ACETONITRILE;[2-(Pyrrolidin-1-yl)phenyl]acetonitrile;DTXSID60524292;EN300-1844639

Suppliers and Price of [2-(Pyrrolidin-1-yl)phenyl]acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-(Pyrrolidin-1-yl)phenyl]acetonitrile

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:186.115698455
Heavy Atom Count:14
Complexity:222

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)C2=CC=CC=C2CC#N

Technology Process of [2-(Pyrrolidin-1-yl)phenyl]acetonitrile

There total 1 articles about [2-(Pyrrolidin-1-yl)phenyl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 110-52-1
1,4-dibromo-butane

: 2973-50-4
2-aminophenylacetonitrile

: 87698-85-9
2-(1-pyrrolidinyl)benzeneacetonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 110 ℃; for 4h;
DOI:10.1021/jo00176a011

Reference yield: 88.0%

: 87698-85-9
2-(1-pyrrolidinyl)benzeneacetonitrile

: 100-52-7
benzaldehyde

: 87698-87-1,87698-88-2
α-(Phenylmethylene)-2-(1-pyrrolidinyl)-benzeneacetonitrile

Guidance literature:: With sodium ethanolate; In ethanol; at 78.5 ℃; for 3h;
DOI:10.1021/jo00176a011

Reference yield:

: 87698-85-9
2-(1-pyrrolidinyl)benzeneacetonitrile

: 91147-58-9,91147-59-0
α-(methoxymethylene)-2-(1-pyrrolidinyl)benzeneacetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) reflux, 2 hr, toluene; 2.) 50-60 deg C, 4 hours

2: 86 percent / dimethylformamide / 2 h / Ambient temperature

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)90103-0