N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-phenylalanyl-L-threonine

Base Information

• Chemical Name: N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-phenylalanyl-L-threonine
• CAS No.: 87720-57-8
• Molecular Formula: C28H28N2O6
• Molecular Weight: 488.53200
• DSSTox Substance ID: DTXSID40562657
• Nikkaji Number: J452.719D
• Wikidata: Q82446906

Synonyms:87720-57-8;DTXSID40562657;N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-phenylalanyl-L-threonine

Chemical Property of N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-phenylalanyl-L-threonine

Chemical Property:

• Boiling Point: 800.1±65.0 °C(Predicted)
• PSA: 131.94000
• Density: 1.307±0.06 g/cm3(Predicted)
• LogP: 4.13130
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 488.19473662
• Heavy Atom Count: 36
• Complexity: 747

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)O
• Isomeric SMILES: C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)O

Technology Process of N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-phenylalanyl-L-threonine

There total 6 articles about N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-phenylalanyl-L-threonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Fmoc-Phe-Thr-OMe (139928-73-7) → Nα-fluoren-9-ylmethyloxycarbonyl-L-phenylalanyl-L-threonine (87720-57-8)

Guidance literature:

With phosphate buffer; In tert-butyl alcohol; at 35 ℃; alcalase;

DOI:10.1080/00397919208055416

Reference yield: 70.0%

L-threonine (72-19-5,134357-96-3,7013-32-3,82822-12-6) + Fmoc-Phe-benzotriazolyl ester (127633-31-2) → Nα-fluoren-9-ylmethyloxycarbonyl-L-phenylalanyl-L-threonine (87720-57-8)

Guidance literature:

With benzyltrimethylammonium chloride; In chloroform; for 3h; Ambient temperature;

DOI:10.1039/c39900001045

Reference yield: 68.0%

t-butyl-N-fluoren-9-ylmethyloxycarbonyl-L-phenylalanyl-O-t-butyl-L-threonine (87720-56-7) → Nα-fluoren-9-ylmethyloxycarbonyl-L-phenylalanyl-L-threonine (87720-57-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1039/P19830000723

upstream raw materials:

L-threonine

Fmoc-Phe-benzotriazolyl ester

Fmoc-Phe-Thr-OMe

t-butyl-N-fluoren-9-ylmethyloxycarbonyl-L-phenylalanyl-O-t-butyl-L-threonine

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