L-Threonine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester

Base Information

• Chemical Name: L-Threonine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester
• CAS No.: 139928-73-7
• Molecular Formula: C29H30N2O6
• Molecular Weight: 502.567
• Mol file: 139928-73-7.mol

Synonyms:

Chemical Property of L-Threonine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Threonine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester

There total 2 articles about L-Threonine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Fmoc L-Phe (35661-40-6) → Fmoc-Phe-Thr-OMe (139928-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / ethyl acetate; dimethylformamide / 6 h / Ambient temperature

2: diisopropylethylamine / CH₂Cl₂; dimethylformamide; ethyl acetate / 4 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1080/00397919208055416

Reference yield:

L-threonine methyl ester hydrochloride (39994-75-7) + Fmoc-Phe-benzotriazolyl ester (127633-31-2) → Fmoc-Phe-Thr-OMe (139928-73-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; for 4h; Yield given; Ambient temperature;

DOI:10.1080/00397919208055416

Reference yield: 83.0%

Fmoc-Phe-Thr-OMe (139928-73-7) → Nα-fluoren-9-ylmethyloxycarbonyl-L-phenylalanyl-L-threonine (87720-57-8)

Guidance literature:

With phosphate buffer; In tert-butyl alcohol; at 35 ℃; alcalase;

DOI:10.1080/00397919208055416

upstream raw materials:

L-threonine methyl ester hydrochloride

Fmoc-Phe-benzotriazolyl ester

N-Fmoc L-Phe

Downstream raw materials:

N^α-fluoren-9-ylmethyloxycarbonyl-L-phenylalanyl-L-threonine