1H-Indazole-1-carboxylicacid,5-(2-broMoacetyl)-,1,1-diMethylethylester

Base Information

• Chemical Name: 1H-Indazole-1-carboxylicacid,5-(2-broMoacetyl)-,1,1-diMethylethylester
• CAS No.: 877264-74-9
• Molecular Formula: C₁₄H₁₅BrN₂O₃
• Molecular Weight: 339.189
• Mol file: 877264-74-9.mol

Synonyms:

Chemical Property of 1H-Indazole-1-carboxylicacid,5-(2-broMoacetyl)-,1,1-diMethylethylester

Chemical Property:

• PSA: 61.19000
• LogP: 3.39710

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indazole-1-carboxylicacid,5-(2-broMoacetyl)-,1,1-diMethylethylester

There total 4 articles about 1H-Indazole-1-carboxylicacid,5-(2-broMoacetyl)-,1,1-diMethylethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 5-acetyl-1H-indazole-1-carboxylate (877264-73-8) → tert-butyl 5-(2-bromoacetyl)-1H-indazole-1-carboxylate (877264-74-9)

Guidance literature:

With pyridinium hydrobromide perbromide; In tetrahydrofuran; at 40 ℃; for 2h;

Reference yield:

tert-butyl 5-bromo-1H-indazole-1-carboxylate (651780-02-8) → tert-butyl 5-(2-bromoacetyl)-1H-indazole-1-carboxylate (877264-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C

2: pyridinium hydrobromide perbromide / tetrahydrofuran / 2 h / 40 °C

With pyridinium hydrobromide perbromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; toluene;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-(2-bromoacetyl)-1H-indazole-1-carboxylate (877264-74-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / dichloromethane / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C

3: pyridinium hydrobromide perbromide / tetrahydrofuran / 2 h / 40 °C

With dmap; pyridinium hydrobromide perbromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; toluene;

upstream raw materials:

tert-butyl 5-acetyl-1H-indazole-1-carboxylate

tert-butyl 5-bromo-1H-indazole-1-carboxylate

di-tert-butyl dicarbonate

5-bromo-1H-indazole