877264-73-8

Usage

Uses

Used in Pharmaceutical Synthesis:
1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-dimethylethyl ester is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, particularly in the fields of medicinal chemistry and drug discovery.
Used in Material Sciences:
1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-dimethylethyl ester is used as a building block in the creation of new materials with specific properties. Its chemical structure can be manipulated to achieve desired characteristics, making it a valuable asset in the field of material sciences.
Used in Chemical Research:
1H-Indazole-1-carboxylic acid, 5-acetyl-, 1,1-dimethylethyl ester is used as a research compound in various chemical studies. Its properties and reactivity can provide insights into the behavior of similar compounds, contributing to the broader understanding of organic chemistry.

Upstream product

• 1001907-23-8 tert-butyl 5-iodo-1H-indazole-1-carboxylate 
• 111-34-2 -butyl vinyl ether 
• 651780-02-8 tert-butyl 5-bromo-1H-indazole-1-carboxylate 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 61700-61-6 1H-indazole-5-carboxylic acid 
• 53857-57-1 5-bromo-1H-indazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1093306-90-1 N-methoxy-N-methyl-1H-indazole-5-carboxamide 
• 1001906-63-3 1-(1H-indazole-5-yl)-ethanone 

Downstream Products

• 1001906-63-3 1-(1H-indazole-5-yl)-ethanone 
• 877264-74-9 tert-butyl 5-(2-bromoacetyl)-1H-indazole-1-carboxylate 
• 1093302-85-2 4-(1H-indazol-5-yl)-N-phenyl-1,3-thiazol-2-amine 
• 1093302-88-5 N-benzyl-4-(1H-indazol-5-yl)-1,3-thiazol-2-amine 
• 1093302-90-9 4-(1H-indazol-5-yl)-N-(2-phenylethyl)-1,3-thiazol-2-amine 

Relevant academic research and scientific papers

Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions

We report the synthesis and biological evaluation of 5-substituted indazoles as kinase inhibitors. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing heterocycle forming and multicomponent reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for Gsk3β, Rock2, and Egfr.

5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

SUBSTITUTED N-BICYCLICALKYL BICYCLIC CARBOXYAMIDE COMPOUNDS

This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition compri