2-iodo-6-methoxyBenzenemethanol

Base Information

• Chemical Name: 2-iodo-6-methoxyBenzenemethanol
• CAS No.: 877265-22-0
• Molecular Formula: C8H9IO2
• Molecular Weight: 264.063
• Hs Code.: 2909499000
• Mol file: 877265-22-0.mol

Synonyms:2-IODO-4-TRIFLUOROMETHYLBENZYL ALCOHOL;

Chemical Property of 2-iodo-6-methoxyBenzenemethanol

Chemical Property:

• PSA: 29.46000
• LogP: 1.79210

Purity/Quality:

(2-Iodo-6-methoxy-phenyl)-methanol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-iodo-6-methoxyBenzenemethanol

There total 2 articles about 2-iodo-6-methoxyBenzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-benzyl-2-iodo-6-methoxybenzamide (66195-39-9) → (2-iodo-6-methoxyphenyl)methanol (877265-22-0)

Guidance literature:

With borane; In tetrahydrofuran; Heating;

DOI:10.1016/j.tetlet.2006.08.065

Reference yield:

6-methoxyanthranilic acid (53600-33-2) → (2-iodo-6-methoxyphenyl)methanol (877265-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 90 °C / Inert atmosphere

2.1: Trimethyl borate; dimethylsulfide borane complex / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

With hydrogenchloride; Trimethyl borate; dimethylsulfide borane complex; sodium nitrite; In tetrahydrofuran; water;

DOI:10.1021/acs.orglett.7b03577

Reference yield: 84.0%

(2-iodo-6-methoxyphenyl)methanol (877265-22-0) → 2-iodo-6-methoxybenzaldehyde (5025-59-2)

Guidance literature:

With dipyridinium dichromate; silica gel; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03577

upstream raw materials:

N-benzyl-2-iodo-6-methoxybenzamide

6-methoxyanthranilic acid

Downstream raw materials:

1-iodo-2-iodomethyl-3-methoxy-benzene

1-(2-iodo-6-methoxy-benzyl)-1H-benzo[cd]indol-3-one

3-acetyl-1-(2-iodo-6-methoxy-benzyl)-1H-indole-4-carbaldehyde

2-iodo-6-methoxybenzaldehyde