[(Z)-[1-[4-[[Tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethylidene]amino] 4-methylbenzenesulfonate

Base Information

Chemical Name:[(Z)-[1-[4-[[Tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethylidene]amino] 4-methylbenzenesulfonate
CAS No.:87736-80-9
Molecular Formula:C22H28F3NO4SSi
Molecular Weight:487.615
Hs Code.:
DSSTox Substance ID:DTXSID60516859
Mol file:87736-80-9.mol

Synonyms:87736-80-9;[(Z)-[1-[4-[[Tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethylidene]amino] 4-methylbenzenesulfonate;DTXSID60516859;(1Z)-1-[4-({[tert-Butyl(dimethyl)silyl]oxy}methyl)phenyl]-2,2,2-trifluoro-N-[(4-methylbenzene-1-sulfonyl)oxy]ethan-1-imine

Suppliers and Price of [(Z)-[1-[4-[[Tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethylidene]amino] 4-methylbenzenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[2,2,2-Trifluoroethyl-1-O-((4-methylphenyl)sulfonyl)oxime]benzylAlcoholtert-Butyl(dimethyl)silylEther
250mg
$ 1320.00

Total 3 raw suppliers

Chemical Property of [(Z)-[1-[4-[[Tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethylidene]amino] 4-methylbenzenesulfonate

Chemical Property:

PSA：73.34000
LogP:7.26950
Storage Temp.:Refrigerator
Solubility.:Dichloromethane, Ehtyl Acetate, Methanol
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:487.14604057
Heavy Atom Count:32
Complexity:741

Purity/Quality:: 4-[2,2,2-Trifluoroethyl-1-O-((4-methylphenyl)sulfonyl)oxime]benzylAlcoholtert-Butyl(dimethyl)silylEther ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)ON=C(C2=CC=C(C=C2)CO[Si](C)(C)C(C)(C)C)C(F)(F)F
Isomeric SMILES:CC1=CC=C(C=C1)S(=O)(=O)O/N=C(/C2=CC=C(C=C2)CO[Si](C)(C)C(C)(C)C)\C(F)(F)F

Technology Process of [(Z)-[1-[4-[[Tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethylidene]amino] 4-methylbenzenesulfonate

There total 15 articles about [(Z)-[1-[4-[[Tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-2,2,2-trifluoroethylidene]amino] 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 87736-77-4
4-[(tert-butyldimethylsiloxy)methyl]-2,2,2-trifluoroacetophenone oxime

: 98-59-9
p-toluenesulfonyl chloride

: 87736-80-9
4-[(tert-butyldimethylsiloxy)methyl]-2,2,2-trifluoroacetophenone-O-(4-toluenesulfonyl) oxime

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/b813504e

Reference yield: 70.0%

: 87736-77-4
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone oxime

: 98-59-9
p-toluenesulfonyl chloride

: 87736-80-9
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone O-(p-tolylsulfonyl)oxime

Guidance literature:: In pyridine; for 3h; Heating;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 87736-80-9
4-[(tert-butyldimethylsiloxy)methyl]-2,2,2-trifluoroacetophenone-O-(4-toluenesulfonyl) oxime

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / imidazole / dimethylformamide

2: 93 percent / nBuLi / tetrahydrofuran; hexane / 1.25 h / -74 °C

3: 1.) NH₂OH*HCl, pyridine; 2.) N,N-diisopropylethylamine, 4-dimethylaminopyridine / 1.) EtOH; 2.) CH₂Cl₂, r.t.

With pyridine; 1H-imidazole; dmap; n-butyllithium; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)60743-8