Cyclopentanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

Base Information

Chemical Name:Cyclopentanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-
CAS No.:141283-85-4
Molecular Formula:C₁₃H₁₆F₃N₃O₃S
Molecular Weight:351.35
Hs Code.:
DSSTox Substance ID:DTXSID60161641
Wikidata:Q83030081

Synonyms:141283-85-4;Cyclopentanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-;N-(2-((Methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)cyclopentanecarboxamide;SCHEMBL154726;C13H16F3N3O3S;DTXSID60161641;IWXQIOFKHRRNRK-UHFFFAOYSA-N;C13-H16-F3-N3-O3-S;LS-57858

Suppliers and Price of Cyclopentanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Cyclopentanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.498g/cm³
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:351.08644704
Heavy Atom Count:23
Complexity:527

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)NC1=C(C=C(C=N1)C(F)(F)F)NC(=O)C2CCCC2

Technology Process of Cyclopentanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-

There total 4 articles about Cyclopentanecarboxamide, N-(2-((methylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 4524-93-0
Cyclopentanecarboxylic acid chloride

: 141284-81-3
N-(3-amino-5-trifluoromethyl-pyridin-2-yl)-methanesulfonamide

: 141283-85-4
N-(2-methylsulfonylamino-5-trifluoromethyl-pyridin-3-yl)cyclopentanecarboxamide

Guidance literature:: In tetrahydrofuran; Ambient temperature;
DOI:10.1248/cpb.43.1696

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 141283-85-4
N-(2-methylsulfonylamino-5-trifluoromethyl-pyridin-3-yl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylsulfoxide / 7 h / 110 - 120 °C

2: 94percent aq. HNO₃ / acetic acid / 6 h / 105 - 110 °C

3: Fe, CH₃COOH / 1 h / 65 °C

4: 92 percent / tetrahydrofuran / Ambient temperature

With nitric acid; iron; potassium carbonate; acetic acid; In tetrahydrofuran; acetic acid; dimethyl sulfoxide;
DOI:10.1248/cpb.43.1696

Reference yield:

: 141284-83-5
N-[5-(Trifluoromethyl)pyridin-2-yl]methanesulfonamide

: 141283-85-4
N-(2-methylsulfonylamino-5-trifluoromethyl-pyridin-3-yl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94percent aq. HNO₃ / acetic acid / 6 h / 105 - 110 °C

2: Fe, CH₃COOH / 1 h / 65 °C

3: 92 percent / tetrahydrofuran / Ambient temperature

With nitric acid; iron; acetic acid; In tetrahydrofuran; acetic acid;
DOI:10.1248/cpb.43.1696