Methyl 5-(bromomethyl)nicotinate

Base Information

• Chemical Name: Methyl 5-(bromomethyl)nicotinate
• CAS No.: 877624-38-9
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.061
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40565663
• Wikidata: Q82450880
• Mol file: 877624-38-9.mol

Synonyms:METHYL 5-(BROMOMETHYL)NICOTINATE;877624-38-9;METHYL 5-(BROMOMETHYL)PYRIDINE-3-CARBOXYLATE;5-Bromomethylnicotinic acid methyl ester;Methyl 5-bromomethylpyridine-3-carboxylate;Methyl5-(bromomethyl)nicotinate;3-Pyridinecarboxylic acid, 5-(bromomethyl)-, methyl ester;SCHEMBL3938261;DTXSID40565663;AEZXIAKNBQNDPO-UHFFFAOYSA-N;CKB62438;CS-D1642;AKOS015836039;DS-15627;J-522409

Chemical Property of Methyl 5-(bromomethyl)nicotinate

Chemical Property:

• PSA: 39.19000
• LogP: 2.72120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.97384
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

Methyl 5-(bromomethyl)pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=CN=CC(=C1)CBr

Technology Process of Methyl 5-(bromomethyl)nicotinate

There total 2 articles about Methyl 5-(bromomethyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

5-methylnicotinic acid methyl ester (29681-45-6) → methyl 5-(bromomethyl)nicotinate (877624-38-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 10h; Reflux; Inert atmosphere;

DOI:10.1021/ja402810t

Reference yield:

→ methyl 5-(bromomethyl)nicotinate (877624-38-9)

Guidance literature:

Reference yield: 82.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + methyl 5-(bromomethyl)nicotinate (877624-38-9) → methyl 5-((4-formyl-6-methoxyphen-3-yloxy)methyl)nicotinate (1446322-14-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

5-methylnicotinic acid methyl ester

Downstream raw materials:

C₁₅H₁₅NO₃

methyl 5-((4-formyl-6-methoxyphen-3-yloxy)methyl)nicotinate