1-Piperidinecarboxylic acid, 4-(4-Methoxyphenyl)-4-(2-oxoethyl)-,1,1-diMethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-(4-Methoxyphenyl)-4-(2-oxoethyl)-,1,1-diMethylethyl ester
CAS No.:878130-45-1
Molecular Formula:C₁₉H₂₇NO₄
Molecular Weight:333.428
Hs Code.:
Mol file:878130-45-1.mol

Synonyms:1-Piperidinecarboxylic acid, 4-(4-methoxyphenyl)-4-(2-oxoethyl)-, 1,1-dimethylethyl ester;

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Chemical Property of 1-Piperidinecarboxylic acid, 4-(4-Methoxyphenyl)-4-(2-oxoethyl)-,1,1-diMethylethyl ester

Chemical Property:

PSA：55.84000
LogP:3.49080

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 1-Piperidinecarboxylic acid, 4-(4-Methoxyphenyl)-4-(2-oxoethyl)-,1,1-diMethylethyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 4-(4-Methoxyphenyl)-4-(2-oxoethyl)-,1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 878130-38-2
4-cyanomethyl-4-(4-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

: 878130-45-1
4-(4-methoxy-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -40 ℃; for 1h;
DOI:10.1080/00397910500374971

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 878130-45-1
4-(4-methoxy-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / 20 °C

1.2: copper(I) iodide / tetrahydrofuran / 0 - 20 °C

2.1: sodium hydroxide / ethanol; H₂O / 6.5 h / 20 °C

3.1: copper(I) oxide / acetonitrile / 0.5 h / Heating

4.1: 69 percent / DIBAL-H / CH₂Cl₂ / 1 h / -40 °C

With copper(I) oxide; sodium hydroxide; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 1.2: Grignard addition;
DOI:10.1080/00397910500374971

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 878130-45-1
4-(4-methoxy-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / NH₄OAc; AcOH; benzene

2.1: magnesium / tetrahydrofuran / 20 °C

2.2: copper(I) iodide / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydroxide / ethanol; H₂O / 6.5 h / 20 °C

4.1: copper(I) oxide / acetonitrile / 0.5 h / Heating

5.1: 69 percent / DIBAL-H / CH₂Cl₂ / 1 h / -40 °C

With copper(I) oxide; sodium hydroxide; ammonium acetate; diisobutylaluminium hydride; magnesium; acetic acid; benzene; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 2.2: Grignard addition;
DOI:10.1080/00397910500374971