Tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
CAS No.:193537-11-0
Molecular Formula:C15H22 N2 O4
Molecular Weight:294.351
Hs Code.:2933399090
DSSTox Substance ID:DTXSID90468458
Nikkaji Number:J2.283.216F
Mol file:193537-11-0.mol

Synonyms:193537-11-0;TERT-BUTYL 4-(1-CYANO-2-ETHOXY-2-OXOETHYLIDENE)PIPERIDINE-1-CARBOXYLATE;MFCD11977347;tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate;4-(1-Cyano-2-ethoxy-2-oxoethylidene)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 4-(1-cyano-2-ethoxy-2-oxoethylidene)-, 1,1-dimethylethyl ester;SCHEMBL344971;DTXSID90468458;FYSWQLWLYPQLMR-UHFFFAOYSA-N;AKOS015897885;AM803445;NS-04952;SY124103;CS-0046864;A813648;Ethyl 2-(1-Boc-piperidin-4-ylidene)-2-cyanoacetate;tert-butyl-4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Suppliers and Price of Tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 95+%
1g
$ 439.00

Crysdot
tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 95+%
250mg
$ 255.00

Chemenu
tert-butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 95%
1g
$ 282.00

Chemenu
tert-butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 95%
5g
$ 904.00

American Custom Chemicals Corporation
TERT-BUTYL-4-(1-CYANO-2-ETHOXY-2-OXOETHYLIDENE)PIPERIDINE-1-CARBOXYLATE 95.00%
5MG
$ 501.26

Alichem
tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
5g
$ 1004.85

AK Scientific
tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
5g
$ 2491.00

AK Scientific
tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
1g
$ 864.00

AK Scientific
tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
250mg
$ 371.00

Total 6 raw suppliers

Chemical Property of Tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Chemical Property:

PSA：79.63000
LogP:2.33848
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:294.15795719
Heavy Atom Count:21
Complexity:484

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=C1CCN(CC1)C(=O)OC(C)(C)C)C#N

Technology Process of Tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

There total 2 articles about Tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 105-56-6
ethyl 2-cyanoacetate

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

Guidance literature:: With ammonium acetate; acetic acid; benzene;
DOI:10.1080/00397910500374971

Reference yield: 33.84%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 64-19-7,77671-22-8
acetic acid

: 372-09-8
cyanoacetic acid

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

Guidance literature:: With ammonium acetate; In toluene; at 95 - 130 ℃; for 3h; Reflux; Large scale;

Reference yield: 100.0%

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 60811-21-4
1-bromo-3-chloro-4-fluorobenzene

: 716359-69-2
t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: 1-bromo-3-chloro-4-fluorobenzene; With magnesium; In diethyl ether; at 20 ℃; Inert atmosphere;

tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate; With copper(l) iodide; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm200279v