(2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1-one

Base Information

Chemical Name:(2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1-one
CAS No.:16252-53-2
Molecular Formula:C12H12 O3
Molecular Weight:204.225
Hs Code.:
European Community (EC) Number:605-291-3
NSC Number:99370
Mol file:16252-53-2.mol

Synonyms:16252-53-2;NSC99370;NSC-99370

Suppliers and Price of (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1-one

Chemical Property:

Vapor Pressure:1.46E-06mmHg at 25°C
Boiling Point:383.4°Cat760mmHg
Flash Point:152.1°C
Density:1.317g/cm³
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:204.078644241
Heavy Atom Count:15
Complexity:283

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(=O)C(=CO)CC2
Isomeric SMILES:COC1=CC2=C(C=C1)C(=O)/C(=C/O)/CC2

Technology Process of (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1-one

There total 3 articles about (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 109-94-4
formic acid ethyl ester

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 16252-53-2
6-Methoxy-2-hydroxymethylen-1-tetralon

Guidance literature:: With potassium tert-butylate; In toluene; at -78 - -5 ℃; Inert atmosphere;

Reference yield:

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 16252-53-2
6-Methoxy-2-hydroxymethylen-1-tetralon

Guidance literature:: 6-methoxy-3,4-dihydro-1(2H)-naphthalenone; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With formic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/acsmedchemlett.6b00390