Boc-lys(Z)-onp

Base Information

• Chemical Name: Boc-lys(Z)-onp
• CAS No.: 2389-46-0
• Molecular Formula: C25H31 N3 O8
• Molecular Weight: 501.536
• Hs Code.: 2924299090
• European Community (EC) Number: 667-965-3
• Mol file: 2389-46-0.mol

Synonyms:BOC-LYS(Z)-ONP;2389-46-0;Nalpha-Boc-Nepsilon-Z-L-lysine 4-nitrophenyl ester;SCHEMBL18560008;FZHFJIODNQYXRK-NRFANRHFSA-N;(4-nitrophenyl) (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoate;MFCD00056137;AKOS015841425;AKOS016003203;Nalpha-BOC-Nepsilon-CBZ-L-lysine p-nitrophenyl ester

Chemical Property of Boc-lys(Z)-onp

Chemical Property:

• Vapor Pressure: 3.5E-18mmHg at 25°C
• Melting Point: 89 °C(Solv: ethanol (64-17-5); water (7732-18-5)(1:1))
• Boiling Point: 676.9°Cat760mmHg
• PKA: 10.82±0.46(Predicted)
• Flash Point: 363.2°C
• PSA: 148.78000
• Density: 1.234g/cm³
• LogP: 5.79520
• Storage Temp.: -15°C
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 14
• Exact Mass: 501.21111496
• Heavy Atom Count: 36
• Complexity: 720

Purity/Quality:

97% ^*data from raw suppliers

N-alpha-Boc-Nε-Z-L-lysine 4-nitrophenyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CCCCNC(=O)OCC1=CC=CC=C1)C(=O)OC2=CC=C(C=C2)[N+](=O)[O-]
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCC1=CC=CC=C1)C(=O)OC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of Boc-lys(Z)-onp

There total 6 articles about Boc-lys(Z)-onp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Boc-Lys(Z)-OH (2389-45-9) → N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester (2389-46-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate;

Reference yield:

N-(tert-butyloxycarbonyl) azide (1070-19-5) → N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester (2389-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N

2: 88 percent / DCC / ethyl acetate

With triethylamine; dicyclohexyl-carbodiimide; In ethyl acetate;

Reference yield:

N6-[(benzyloxy)carbonyl]-L-lysine (1155-64-2,57705-97-2,67178-46-5,25931-47-9) → N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester (2389-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N

2: 88 percent / DCC / ethyl acetate

With triethylamine; dicyclohexyl-carbodiimide; In ethyl acetate;

upstream raw materials:

4-nitro-phenol

N-(tert-butyloxycarbonyl) azide

N₆-[(benzyloxy)carbonyl]-L-lysine

Boc-Lys(Z)-OH

Downstream raw materials:

N^ε-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-L-lysinamide

(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid

N^α-BOC-N^ε-Z-Lys-Pro-OMe

Boc-Lys(Z)-Thr-Val-OMe