4,6-bis(aziridin-1-yl)-2-(naphthalen-2-yl)-5-nitropyrimidine

Base Information

• Chemical Name: 4,6-bis(aziridin-1-yl)-2-(naphthalen-2-yl)-5-nitropyrimidine
• CAS No.: 64440-96-6
• Molecular Formula: C₁₈H₁₅N₅O₂
• Molecular Weight: 333.349
• Mol file: 64440-96-6.mol

Synonyms:Pyrimidine,4,6-bis(1-aziridinyl)-2-(2-naphthyl)-5-nitro- (5CI)

Chemical Property of 4,6-bis(aziridin-1-yl)-2-(naphthalen-2-yl)-5-nitropyrimidine

Chemical Property:

• Vapor Pressure: 5.1E-10mmHg at 25°C
• Boiling Point: 497.1°Cat760mmHg
• Flash Point: 254.4°C
• Density: 1.48g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-bis(aziridin-1-yl)-2-(naphthalen-2-yl)-5-nitropyrimidine

There total 4 articles about 4,6-bis(aziridin-1-yl)-2-(naphthalen-2-yl)-5-nitropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2]naphthyl-1H-pyrimidine-4,6-dione → 4,6-bis-aziridin-1-yl-2-[2]naphthyl-5-nitro-pyrimidine (64440-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous HNO₃

2: N,N-dimethyl-aniline; POCl₃

With nitric acid; N,N-dimethyl-aniline; trichlorophosphate;

DOI:10.1093/qjmed/93.9.639

Reference yield:

2-[2]naphthyl-5-nitro-1H-pyrimidine-4,6-dione → 4,6-bis-aziridin-1-yl-2-[2]naphthyl-5-nitro-pyrimidine (64440-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-aniline; POCl₃

With N,N-dimethyl-aniline; trichlorophosphate;

DOI:10.1093/qjmed/93.9.639

Reference yield:

2-naphthalenecarboxamidine hydrochloride (14948-94-8) → 4,6-bis-aziridin-1-yl-2-[2]naphthyl-5-nitro-pyrimidine (64440-96-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanolic sodium ethylate

2: aqueous HNO₃

3: N,N-dimethyl-aniline; POCl₃

With nitric acid; sodium ethanolate; N,N-dimethyl-aniline; trichlorophosphate;

DOI:10.1093/qjmed/93.9.639

upstream raw materials:

ethyleneimine

4,6-dichloro-2-[2]naphthyl-5-nitro-pyrimidine

2-naphthalenecarboxamidine hydrochloride