2-Benzyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole

Base Information

Chemical Name:2-Benzyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole
CAS No.:87954-26-5
Molecular Formula:C17H25NOSi
Molecular Weight:287.477
Hs Code.:
DSSTox Substance ID:DTXSID00528234
Wikidata:Q82397682

Synonyms:87954-26-5;2-Benzyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole;DTXSID00528234

Suppliers and Price of 2-Benzyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Benzyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:7
Exact Mass:287.170540955
Heavy Atom Count:20
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[Si](C)(C)CCOCN1C=CC=C1CC2=CC=CC=C2

Technology Process of 2-Benzyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole

There total 2 articles about 2-Benzyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 100-39-0
benzyl bromide

: 87954-20-9
1-<<(β-trimethylsilyl)ethoxy>methyl>pyrrole

: 87954-26-5
1-<<2-(trimethylsilyl)ethoxy>methyl>-2-benzylpyrrole

Guidance literature:: With tert.-butyl lithium; In hexane; a) -78 deg C, 1h b) 0 deg, 2h c) room temperature, 18h;
DOI:10.1021/jo00175a053

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 87954-26-5
1-<<2-(trimethylsilyl)ethoxy>methyl>-2-benzylpyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaH / dimethylformamide / 1. 0 deg C 2. room temperature, 1h

2: 75 percent / t-BuLi / hexane / a) -78 deg C, 1h b) 0 deg, 2h c) room temperature, 18h

With tert.-butyl lithium; sodium hydride; In hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo00175a053