3-(2,5-dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 3-(2,5-dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde
• CAS No.: 879996-64-2
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• DSSTox Substance ID: DTXSID001219658

Synonyms:3-(2,5-dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde;879996-64-2;5-(2,5-dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde;DTXSID001219658;MFCD10692902;AKOS000266389;AKOS005144397;LS-02401;BB 0249048;CS-0374083;EN300-6503350;3-(2,5-Dimethoxyphenyl)-1H-pyrazole-4-carboxaldehyde;5-(2,5-Dimethoxy-phenyl)-1H-pyrazole-4-car baldehyde;Z3214214696

Chemical Property of 3-(2,5-dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 232.08479225
• Heavy Atom Count: 17
• Complexity: 262

Purity/Quality:

98%min ^*data from raw suppliers

3-(2,5-Dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC)C2=C(C=NN2)C=O

Technology Process of 3-(2,5-dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde

There total 2 articles about 3-(2,5-dimethoxyphenyl)-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(2,5-dimethoxy-phenyl)-ethanone semicarbazone (22138-15-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(2,5-dimethoxy-phenyl)-1H-pyrazole-4-carbaldehyde (879996-64-2)

Guidance literature:

With trichlorophosphate; at 40 - 80 ℃;

DOI:10.1007/s11176-005-0318-7

Reference yield:

2',5'-dimethoxyacetophenone (1201-38-3) → 3-(2,5-dimethoxy-phenyl)-1H-pyrazole-4-carbaldehyde (879996-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AcONa / ethanol / 0.75 h / Heating

1.2: ethanol / 1 h / Heating

2.1: 62 percent / POCl₃ / 40 - 80 °C

With sodium acetate; trichlorophosphate; In ethanol; 2.1: Vilsmeier formylation;

DOI:10.1007/s11176-005-0318-7

upstream raw materials:

1-(2,5-dimethoxy-phenyl)-ethanone semicarbazone

N,N-dimethyl-formamide

2',5'-dimethoxyacetophenone

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