1201-38-3

Basic information

• Product Name: 2',5'-Dimethoxyacetophenone
• Synonyms: Methyl 2,5-dimethoxyphenyl ketone;2,5-Dimethoxy acetonphenone;2',5'-Dimethoxyacetophenone,99%;2',5'-Dimethoxyaceto;1-(2,5-dimethoxyphenyl)-ethanon;Acetophenone, 2',5'-dimethoxy-;AKOS BBS-00004326;1-(2,5-dimethoxyphenyl)-ethanone
• CAS NO: 1201-38-3
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• EINECS: 214-858-0
• Product Categories: C10;Carbonyl Compounds;Ketones;Acetophenone series;Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 1201-38-3.mol
• Article Data: 44

Chemical Properties

• Melting Point: 18-20 °C(lit.)
• Boiling Point: 155-158 °C11 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow to green-yellow/Liquid
• Density: 1.139 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.5441(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol (Slightly)
• BRN: 2047423
• CAS DataBase Reference: 2',5'-Dimethoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',5'-Dimethoxyacetophenone(1201-38-3)
• EPA Substance Registry System: 2',5'-Dimethoxyacetophenone(1201-38-3)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 1201-38-3(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to green-yellow liquid

Uses

2'',5''-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents.

Preparation

Obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide.

Upstream product

• 64-19-7 acetic acid 
• 150-78-7 1,4-dimethoxybezene 
• 75-05-8 acetonitrile 
• 7446-70-0 aluminium trichloride 
• 60-29-7 diethyl ether 
• 75-36-5 acetyl chloride 
• 14568-68-4 1,4-dimethoxy-2-vinylbenzene 
• 75-16-1 methylmagnesium bromide 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 41038-40-8 1-(2,5-bis(methoxy)phenyl)ethan-1-ol 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 72229-44-8 2',5'-dimethoxyacetophenone dimethyl acetal 
• 150-76-5 4-methoxy-phenol 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 145091-58-3 2-(1-ethyl-vinyl)-1,4-dimethoxy-benzene 
• 72667-90-4 dimethyl-1,4-dimethoxyphenylcarbinol 
• 109469-64-9 2-hydroxy-3,2',5'-trimethoxy-trans-chalcone 
• 65547-50-4 1-(2,5-dimethoxy-phenyl)-butane-1,3-dione 
• 142472-12-6 1-(2,5-dimethoxyphenyl)-3-phenyl-1,3-propanedione 
• 135708-40-6 2-(2',5'-dimethoxyphenyl)-2-methyl-1,3-dioxolane 
• 752222-71-2 2',5'-dimethoxy-4-(tetrahydropyran-2-yloxy)chalcone 
• 221194-99-6 1-(2,5-dimethoxyphenyl)-3-hydroxy-9-phenylnonan-1-one 
• 74605-12-2 2-Amino-4-(2',5'-dimethoxy)phenylthiazole 
• 112434-74-9 4-(2,5-Dimethoxy-phenyl)-5-(2,2-dimethyl-chroman-6-ylazo)-thiazol-2-ylamine 
• 110048-16-3 2,3,2',5'-tetramethoxy-trans-chalcone 
• 99865-66-4 1-(2,5-dimethoxy-phenyl)-3-hydroxy-propenone 
• 108950-30-7 1-(2,5-dimethoxy-phenyl)-2-[1,3]dioxolan-2-yl-ethanone 
• 485335-52-2 2-(2,5-dimethoxy-phenyl)-quinoline-4-carboxylic acid 

Relevant articles and documents

Solid supported Ru(0) nanoparticles: An efficient ligand-free heterogeneous catalyst for aerobic oxidation of benzylic and allylic alcohol to carbonyl

Polymer immobilized stable, spherical ruthenium nanoparticles were prepared, characterized, and acted as a heterogeneous catalyst for the selective benzylic and allylic alcohol oxidation into the corresponding carbonyls using molecular oxygen. The solid supported Ru(0) (SS-Ru) as a heterogeneous catalyst exhibits good reusability and easy separation from the reaction mixture by filtration.

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Preparation method of 2,5-dimethoxyphenylacetic acid

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of 2,5-dimethoxyphenylacetic acid, wherein the preparation method comprises the following steps: A, reacting 1,4-dimethoxybenzene with formaldehyde under the action of hydrogen halide to obtain 2-halomethyl-1,4-dimethoxybenzene; B, reacting 2-halomethyl-1,4-dimethoxybenzene obtained inthe step A with a cyanation reagent, then diluting, washing, drying and concentrating under reduced pressure, and finally carrying out reduced pressure distillation to obtain 2(2,5-dimethoxyphenyl)acetonitrile; and C, hydrolyzing the 2(2,5-dimethoxyphenyl)acetonitrile obtained in the step B, cooling, extracting, merging, drying, concentrating under reduced pressure and purifying to finally obtainthe 2,5-dimethoxyphenylacetic acid. The yield and the total yield of the 2,5-dimethoxyphenylacetic acid obtained by the method disclosed by the invention are both higher than those of the 2,5-dimethoxyphenylacetic acid synthesized by a Willgerodt-Kindler method, and the yield and the total yield of the 2,5-dimethoxyphenylacetic acid are higher than those of 2,5-dimethoxyphenylacetic acid synthesized by the Willgerodt-Kindler method.

Imidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones

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