Benzeneacetic acid, a-phenyl-, 2-propenyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-phenyl-, 2-propenyl ester
• CAS No.: 88017-70-3
• Molecular Formula: C17H16O2
• Molecular Weight: 252.313
• Mol file: 88017-70-3.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-phenyl-, 2-propenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, a-phenyl-, 2-propenyl ester

There total 5 articles about Benzeneacetic acid, a-phenyl-, 2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-allyloxypyridine (5831-77-6) + 2,2-diphenylacetic acid (117-34-0) → allyl 2,2-diphenylacetate (88017-70-3)

Guidance literature:

2-allyloxypyridine; 2,2-diphenylacetic acid; With methyl trifluoromethanesulfonate; In toluene; at 0 - 23 ℃; for 1h; Inert atmosphere;

With potassium carbonate; In toluene; for 1h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.10.085

Reference yield: 92.0%

2,2-diphenylacetic acid (117-34-0) + allyl alcohol (107-18-6) → allyl 2,2-diphenylacetate (88017-70-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1055/s-0034-1378379

Reference yield: 67.0%

2,2-diphenylacetic acid (117-34-0) + 1-Phenyl-3-buten-1-ol (80735-94-0,936-58-3) → allyl 2,2-diphenylacetate (88017-70-3)

Guidance literature:

With palladium diacetate; silver carbonate; In 1,2-dichloro-benzene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol501887a

upstream raw materials:

diphenylacetic acid chloride

allyl alcohol

2,2-diphenylacetic acid

allyl bromide

Downstream raw materials:

2,2-diphenylacetic acid

2-allyl-2,2-diphenylacetic acid

Refernces

• 1、 Strayer, Timothy A.,Culy, Caleb C.,Bunner, Matthew H.,Frank, Amie R.,Albiniak, Philip A.. "In situ synthesis of 2-allyloxy-1-methylpyridinium triflate for the allylation of carboxylic acids". supporting information. p. 6807 - 6809. Retrieved 2016/01/26.
• 2、 Pérez-López, Ana M.,González-Calderón, Dávir,Occorso, Antonio,Galindo-ángel, Javier,Domínguez-Seglar, José F.,Tamayo, Juan A.,Díaz-Gavilán, Mónica,Gómez-Vidal, José A.. "Synthesis of l -octaarginine through microencapsulated palladium-catalyzed allyl ester deprotection". supporting information. p. 2319 - 2322. Retrieved 2015/08/06.